Analysis Tools
neoplasm
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• in 2 of 6 mice at 20 months
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liver/biliary system
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• in 2 of 6 mice at 20 months
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Allele Symbol Allele Name Allele ID |
Mir122tm1.2Kgh targeted mutation 1.2, Kalpana Ghoshal MGI:5448466 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in 2 of 6 mice at 20 months
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• in 2 of 6 mice at 20 months
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Abnormal liver structure in Mir122tm1.2Kgh/Mir122tm1.2Kgh Speer6-ps1Tg(Alb-cre)21Mgn/0 mice
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• increased
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• in tumor-bearing male mice
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• increase in serum gamma-glutamyl transpeptidase
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• in tumor-bearing mice
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• 2-fold as early as 5 weeks of age
• in tumor-bearing mice
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• 2.5-fold at 8 to 10 weeks of age
• at 6 months of age
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• mice exhibit a small increase in de novo triglyceride synthesis compared with control mice
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• as early as 5 weeks of age
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• as early as 5 weeks of age
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• as early as 5 weeks of age
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• in tumor-bearing mice
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• 2.5-fold at 8 to 10 weeks of age
• at 6 months of age
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• increased
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• 2.5-fold at 8 to 10 weeks of age
• at 6 months of age
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• 2.5-fold at 8 to 10 weeks of age
• at 6 months of age
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• at 12 to 17 months, 13 of 26 male mice develop liver tumors
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• in 2 of 20 mice at 12 to 17 months of age
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• mice exhibit a small increase in de novo triglyceride synthesis and reduced triglyceride secretion in the liver compared with control mice
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• steatohepatitis with bridging fibrosis
• recruitment of monocytes and neutrophils to the liver
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• increased proliferation
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• at 12 to 17 months, 13 of 26 male mice develop liver tumors
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• in 2 of 20 mice at 12 to 17 months of age
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• 3-fold in the liver at 10 months
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• 3-fold in the liver at 10 months
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• in tumor-bearing male mice
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• from monocytes and neutrophils in the liver
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• from monocytes and neutrophils in the liver
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• steatohepatitis with bridging fibrosis
• recruitment of monocytes and neutrophils to the liver
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• 3-fold in the liver at 10 months
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• 3-fold in the liver at 10 months
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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