Phenotypes associated with this allele

• Allele Symbol: Tcf21^tm1(cre)Seq
• Allele Name: targeted mutation 1, Susan E Quaggin
• Allele ID: MGI:5446790
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ptch1^tm1Bjw/Ptch1^tm1Bjw Tcf21^tm1(cre)Seq/Tcf21^+	involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ	MGI:5446894
cn2	Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt Tcf21^tm1(cre)Seq/Tcf21^+	involves: 129S1/Sv * 129X1/SvJ	MGI:5446891
cn3	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Tcf21^tm1(cre)Seq/Tcf21^+	involves: 129S1/Sv * 129X1/SvJ	MGI:5446892

Genotype
MGI:5446894

cn1

• Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw; Tcf21^tm1(cre)Seq/Tcf21⁺
• Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality ( J:189643 )

• embryos die at varying timepoints between E12.5 and birth

renal/urinary system

abnormal kidney morphology ( J:189643 )

• kidneys are comparable in size to controls, display numerous abnormal phenotypes

kidney cyst ( J:189643 )

• multiple cysts are observed, with some cysts containing glomeruli, with other cysts originating in the renal tubules

• cysts arise along entire nephron

abnormal kidney collecting duct morphology ( J:189643 )

• collecting ducts are dilated, distorted and winding, with increased cell proliferation in walls of cysts

abnormal kidney pelvis morphology ( J:189643 )

• pelvic area is dilated

neoplasm

increased tumor incidence ( J:189643 )

• lethality is suggested to result from an aggressive embryonic tumor with minimal renal invasion

growth/size/body

kidney cyst ( J:189643 )

• multiple cysts are observed, with some cysts containing glomeruli, with other cysts originating in the renal tubules

• cysts arise along entire nephron

Genotype
MGI:5446891

cn2

• Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt; Tcf21^tm1(cre)Seq/Tcf21⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

neonatal lethality ( J:189643 )

• mutants are born in expected numbers but die within hours of birth

renal/urinary system

kidney cyst ( J:189643 )

• rudimentary kidneys are cystic with only a only a few immature glomeruli and show random disorganized nephrogenic aggregates at periphery

abnormal kidney development ( J:189643 )

• about 20% of E18.5 embryos or neonatal pups exhibit hypoplastic rudimentary kidneys

renal hypoplasia ( J:189643 )

• most kidneys show some degree of hypoplasia

hydroureter ( J:189643 )

• hydroureter with hypoplasia is observed at E18.5 and in PO pups with about 73.5% incidence; these kidneys also exhibit dilated tubules

ureter hypoplasia ( J:189643 )

growth/size/body

kidney cyst ( J:189643 )

• rudimentary kidneys are cystic with only a only a few immature glomeruli and show random disorganized nephrogenic aggregates at periphery

Genotype
MGI:5446892

cn3

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2Kem; Tcf21^tm1(cre)Seq/Tcf21⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

prenatal lethality ( J:189643 )

• embryos die between E12.5 and birth

renal/urinary system

abnormal kidney development ( J:189643 )

• about 33% of mutants have hypoplastic/dysplastic kidneys with a few disorganized glomeruli

renal hypoplasia ( J:189643 )

• most kidneys show some degree of hypoplasia

fused kidneys ( J:189643 )

• at E18.5 about 66.5% of mutants display kidney fusion at the midline

neoplasm

increased tumor incidence ( J:189643 )

• 100% of mutants display embryonic tumor affecting kidney, gut, heart, and lungs, which appears to arise from multiple mesenchymal tissues