All Phenotypes Irx5<tm3Hui> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Irx5^tm3Hui
targeted mutation 3, Chi-Chung Hui
MGI:5444483

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Irx3^tm3Hui/Irx3^tm3Hui Irx5^tm3Hui/Irx5^tm3Hui Isl1^tm1(cre)Sev/Isl1⁺	involves: 129S/Sv	MGI:5444491
cn2	Irx3^tm3Hui/Irx3^tm3Hui Irx5^tm3Hui/Irx5^tm3Hui H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: C57BL/6J * CBA/J	MGI:5444486
cn3	Irx3^tm3Hui/Irx3^tm3Hui Irx5^tm3Hui/Irx5^tm3Hui Tg(Tek-cre)1Ywa/0	involves: C57BL/6 * SJL	MGI:5444490
cn4	Irx3^tm3Hui/Irx3^tm3Hui Irx5^tm3Hui/Irx5^tm3Hui A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺	involves: FVB	MGI:5444495
cn5	Irx3^tm3Hui/Irx3^tm3Hui Irx5^tm3Hui/Irx5^tm3Hui Tg(Nkx2-5-cre)9Eno/0	Not Specified	MGI:5444489
cn6	Irx3^tm3Hui/Irx3^tm3Hui Irx5^tm3Hui/Irx5^tm3Hui Tg(Mef2c-cre)#Blk/0	Not Specified	MGI:5444487
cx7	Irx3^tm3.1Hui/Irx3^tm3.1Hui Irx5^tm3Hui/Irx5^tm3Hui	Not Specified	MGI:5444485

Allelic Composition	Irx3^tm3Hui/Irx3^tm3Hui Irx5^tm3Hui/Irx5^tm3Hui Isl1^tm1(cre)Sev/Isl1⁺
Genetic Background	involves: 129S/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irx3^tm3Hui mutation (0 available); any Irx3 mutation (24 available)
Irx5^tm3Hui mutation (0 available); any Irx5 mutation (30 available)
Isl1^tm1(cre)Sev mutation (1 available); any Isl1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal cardiac outflow tract development ( J:189007 )

• phenocopies abnormalities seen in germ line double null mice

persistent truncus arteriosus ( J:189007 )

double outlet right ventricle ( J:189007 )

abnormal interatrial septum morphology ( J:189007 )

• absence of the dorsal mesenchymal protrusion and the septum primum

atrial septal defect ( J:189007 )

• appears to be due to a defect in the fusion between the atrioventricular endocardial cushions and the dorsal mesenchymal protrusion

atrioventricular septal defect ( J:189007 )

• atrioventricular canal defect

Allelic Composition	Irx3^tm3Hui/Irx3^tm3Hui Irx5^tm3Hui/Irx5^tm3Hui H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Irx3^tm3Hui mutation (0 available); any Irx3 mutation (24 available)
Irx5^tm3Hui mutation (0 available); any Irx5 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:189007 )

N	• no defects in heart morphology are detected

Allelic Composition	Irx3^tm3Hui/Irx3^tm3Hui Irx5^tm3Hui/Irx5^tm3Hui Tg(Tek-cre)1Ywa/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal cardiac outflow tract development ( J:189007 )

• phenocopies abnormalities seen in germ line double null mice

double outlet right ventricle ( J:189007 )

atrial septal defect ( J:189007 )

• appears to be due to a defect in the fusion between the atrioventricular endocardial cushions and the dorsal mesenchymal protrusion

atrioventricular septal defect ( J:189007 )

• atrioventricular canal defect

Allelic Composition	Irx3^tm3Hui/Irx3^tm3Hui Irx5^tm3Hui/Irx5^tm3Hui A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
Genetic Background	involves: FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cf^{Tg(Myh6-cre/Esr1*)1Jmk} mutation (5 available); any A1cf mutation (39 available)
Irx3^tm3Hui mutation (0 available); any Irx3 mutation (24 available)
Irx5^tm3Hui mutation (0 available); any Irx5 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

prolonged PR interval ( J:189007 )

• in tamoxifen treated mice

prolonged QRS complex duration ( J:189007 )

• in tamoxifen treated mice

Allelic Composition	Irx3^tm3Hui/Irx3^tm3Hui Irx5^tm3Hui/Irx5^tm3Hui Tg(Nkx2-5-cre)9Eno/0
Genetic Background	Not Specified

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:189007 )

N	• no defects in heart morphology are detected

Allelic Composition	Irx3^tm3Hui/Irx3^tm3Hui Irx5^tm3Hui/Irx5^tm3Hui Tg(Mef2c-cre)#Blk/0
Genetic Background	Not Specified

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal cardiac outflow tract development ( J:189007 )

• recapitulates outflow tract abnormalities seen in germ line double null mice

double outlet right ventricle ( J:189007 )

Allelic Composition	Irx3^tm3.1Hui/Irx3^tm3.1Hui Irx5^tm3Hui/Irx5^tm3Hui
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irx3^tm3.1Hui mutation (0 available); any Irx3 mutation (24 available)
Irx5^tm3Hui mutation (0 available); any Irx5 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:189007 )

• present at E14.5 but absent by E15.5

cardiovascular system

abnormal cardiac outflow tract development ( J:189007 )

• improper orientation at E11.5

• misalignment at E12.5, such that the aorta is oriented toward the right ventricle

abnormal heart development ( J:189007 )

• defects in the growth of septa primum and secundum at E12.5

double outlet right ventricle ( J:189007 )

abnormal heart septum morphology ( J:189007 )

• defects in the growth of septa primum and secundum at E12.5

abnormal interatrial septum morphology ( J:189007 )

• absence of the dorsal mesenchymal protrusion and the septum primum at E12.5

atrial septal defect ( J:189007 )

• at E12.5

atrioventricular septal defect ( J:189007 )

• membranous ventricular septal defect at the level of the AV canal at E12.5

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