Phenotypes associated with this allele

• Allele Symbol: Syk^{tm2.1(ZAP70)Fkfr}
• Allele Name: targeted mutation 2.1, Friedemann Kiefer
• Allele ID: MGI:5442724
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Syk^tm2.1(ZAP70)Fkfr/Syk^tm2.1(ZAP70)Fkfr	B6.129-Syk^tm2.1(ZAP70)Fkfr	MGI:5443819

Genotype
MGI:5443819

hm1

• Allelic Composition: Syk^{tm2.1(ZAP70)Fkfr}/Syk^{tm2.1(ZAP70)Fkfr}
• Genetic Background: B6.129-Syk^{tm2.1(ZAP70)Fkfr}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:188422 )

N • macrophage exhibit normal Fcgamma receptor-mediated endocytosis

decreased DN1 thymic pro-T cell number ( J:188422 )

increased DN3 thymocyte number ( J:188422 )

arrested B cell differentiation ( J:188422 )

• partially at the pre-BCR checkpoint

• severe defect in pre-B blast formation

• partially arrested at the T2 stage with a preferential selection towards marginal zone fate in the spleen

decreased B cell number ( J:188422 )

• in secondary lymphoid organs

decreased transitional stage B cell number ( J:188422 )

• reduced fractions D through F (small pre-, immature, transitional B) cells

decreased transitional stage T1 B cell number ( J:188422 )

decreased transitional stage T2 B cell number ( J:188422 )

decreased mature B cell number ( J:188422 )

• in the spleen

decreased marginal zone B cell number ( J:188422 )

• however, mice exhibit age-related partial recovery

increased CD4-positive, alpha-beta T cell number ( J:188422 )

• in the spleen

increased CD4-positive, alpha-beta memory T cell number ( J:188422 )

• effector/memory T cells in the spleen

increased CD8-positive, alpha-beta T cell number ( J:188422 )

• in the spleen

increased CD8-positive, alpha-beta memory T cell number ( J:188422 )

• effector/memory T cells in the spleen

abnormal neutrophil physiology ( J:188422 )

• neutrophils exhibit reduced reactive oxygen

abnormal B cell physiology ( J:188422 )

• B cells exhibit diminished calcium response to anti-IgM-induction

increased B cell apoptosis ( J:188422 )

• in IgM+ B cells

decreased IgG1 level ( J:188422 )

decreased IgG2a level ( J:188422 )

decreased IgG2b level ( J:188422 )

increased IgM level ( J:188422 )

increased anti-insulin autoantibody level ( J:188422 )

glomerulonephritis ( J:188422 )

• age-related, autoantibody immune complex-mediated

renal/urinary system

increased mesangial cell number ( J:188422 )

increased urine protein level ( J:188422 )

• mild at 12 weeks

glomerulonephritis ( J:188422 )

• age-related, autoantibody immune complex-mediated

abnormal renal glomerular capsule morphology ( J:188422 )

• increased size

abnormal renal glomerulus basement membrane morphology ( J:188422 )

• increased

expanded mesangial matrix ( J:188422 )

homeostasis/metabolism

decreased circulating creatinine level ( J:188422 )

decreased blood urea nitrogen level ( J:188422 )

increased circulating glucose level ( J:188422 )

• in fasted mice

increased urine protein level ( J:188422 )

• mild at 12 weeks

cellular

increased mesangial cell number ( J:188422 )

increased B cell apoptosis ( J:188422 )

• in IgM+ B cells

hematopoietic system

decreased DN1 thymic pro-T cell number ( J:188422 )

increased DN3 thymocyte number ( J:188422 )

arrested B cell differentiation ( J:188422 )

• partially at the pre-BCR checkpoint

• severe defect in pre-B blast formation

• partially arrested at the T2 stage with a preferential selection towards marginal zone fate in the spleen

decreased bone marrow cell number ( J:188422 )

decreased B cell number ( J:188422 )

• in secondary lymphoid organs

decreased transitional stage B cell number ( J:188422 )

• reduced fractions D through F (small pre-, immature, transitional B) cells

decreased transitional stage T1 B cell number ( J:188422 )

decreased transitional stage T2 B cell number ( J:188422 )

decreased mature B cell number ( J:188422 )

• in the spleen

decreased marginal zone B cell number ( J:188422 )

• however, mice exhibit age-related partial recovery

increased CD4-positive, alpha-beta T cell number ( J:188422 )

• in the spleen

increased CD4-positive, alpha-beta memory T cell number ( J:188422 )

• effector/memory T cells in the spleen

increased CD8-positive, alpha-beta T cell number ( J:188422 )

• in the spleen

increased CD8-positive, alpha-beta memory T cell number ( J:188422 )

• effector/memory T cells in the spleen

abnormal neutrophil physiology ( J:188422 )

• neutrophils exhibit reduced reactive oxygen

abnormal B cell physiology ( J:188422 )

• B cells exhibit diminished calcium response to anti-IgM-induction

increased B cell apoptosis ( J:188422 )

• in IgM+ B cells

decreased IgG1 level ( J:188422 )

decreased IgG2a level ( J:188422 )

decreased IgG2b level ( J:188422 )

increased IgM level ( J:188422 )

endocrine/exocrine glands

decreased DN1 thymic pro-T cell number ( J:188422 )

increased DN3 thymocyte number ( J:188422 )