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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccm2ltm1Mlkn
targeted mutation 1, Mark L Kahn
MGI:5439489
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccm2ltm1Mlkn/Ccm2ltm1Mlkn involves: 129 * C57BL/6 MGI:5439506
cn2
 		Ccm2ltm1Mlkn/Ccm2ltm1Mlkn
Ccm2tm1Mlkn/Ccm2+
Heg1tm1Mlkn/Heg1tm2.1Mlkn
Tg(Tek-cre)1Ywa/0 		involves: 129 * C57BL/6 * SJL MGI:5439515
cn3
 		Ccm2ltm1Mlkn/Ccm2ltm1Mlkn
Heg1tm1Mlkn/Heg1tm2.1Mlkn
Tg(Tek-cre)1Ywa/0 		involves: 129 * C57BL/6 * SJL MGI:5439509
cx4
 		Ccm2ltm1Mlkn/Ccm2ltm1Mlkn
Ccm2Gt(RRG051)Byg/Ccm2+ 		involves: 129 * 129P2/OlaHsd * C57BL/6 MGI:5439511
cx5
 		Ccm2ltm1Mlkn/Ccm2ltm1Mlkn
Ccm2Gt(RRG051)Byg/Ccm2+
Heg1tm1Mlkn/Heg1tm1Mlkn 		involves: 129 * 129P2/OlaHsd * C57BL/6 MGI:5439510
cx6
 		Ccm2ltm1Mlkn/Ccm2ltm1Mlkn
Heg1tm1Mlkn/Heg1tm1Mlkn 		involves: 129 * C57BL/6 MGI:5439507


Genotype
MGI:5439506
hm1
Allelic
Composition		 Ccm2ltm1Mlkn/Ccm2ltm1Mlkn
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2ltm1Mlkn mutation (0 available); any Ccm2l mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:187714 )
N
• viable
decreased susceptibility to induced morbidity/mortality ( J:187714 )
• protected from lethality because of pulmonary metastases following tail vein injection of LLC cells

neoplasm
abnormal tumor vascularization ( J:187714 )
• tumors derived from injected LLC cells appear paler and are poorly vascularlized
decreased metastatic potential ( J:187714 )
• of tumors derived from injected LLC cells
decreased tumor growth/size ( J:187714 )
• impaired tumor growth following injection of Lewis Lung Carcinoma (LLC) cells

cardiovascular system
abnormal tumor vascularization ( J:187714 )
• tumors derived from injected LLC cells appear paler and are poorly vascularlized

homeostasis/metabolism
delayed wound healing ( J:187714 )
• significantly delayed following full thickness skin punch biopsy




Genotype
MGI:5439515
cn2
Allelic
Composition		 Ccm2ltm1Mlkn/Ccm2ltm1Mlkn
Ccm2tm1Mlkn/Ccm2+
Heg1tm1Mlkn/Heg1tm2.1Mlkn
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2ltm1Mlkn mutation (0 available); any Ccm2l mutation (14 available)
Ccm2tm1Mlkn mutation (0 available); any Ccm2 mutation (47 available)
Heg1tm1Mlkn mutation (0 available); any Heg1 mutation (56 available)
Heg1tm2.1Mlkn mutation (0 available); any Heg1 mutation (56 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:187714 )
• some survivors are detected




Genotype
MGI:5439509
cn3
Allelic
Composition		 Ccm2ltm1Mlkn/Ccm2ltm1Mlkn
Heg1tm1Mlkn/Heg1tm2.1Mlkn
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2ltm1Mlkn mutation (0 available); any Ccm2l mutation (14 available)
Heg1tm1Mlkn mutation (0 available); any Heg1 mutation (56 available)
Heg1tm2.1Mlkn mutation (0 available); any Heg1 mutation (56 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system

muscle




Genotype
MGI:5439511
cx4
Allelic
Composition		 Ccm2ltm1Mlkn/Ccm2ltm1Mlkn
Ccm2Gt(RRG051)Byg/Ccm2+
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2Gt(RRG051)Byg mutation (0 available); any Ccm2 mutation (47 available)
Ccm2ltm1Mlkn mutation (0 available); any Ccm2l mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:187714 )
• viable and fertile




Genotype
MGI:5439510
cx5
Allelic
Composition		 Ccm2ltm1Mlkn/Ccm2ltm1Mlkn
Ccm2Gt(RRG051)Byg/Ccm2+
Heg1tm1Mlkn/Heg1tm1Mlkn
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2Gt(RRG051)Byg mutation (0 available); any Ccm2 mutation (47 available)
Ccm2ltm1Mlkn mutation (0 available); any Ccm2l mutation (14 available)
Heg1tm1Mlkn mutation (0 available); any Heg1 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
abnormal cardiovascular development ( J:187714 )
• about half exhibit normal cardiovascular development




Genotype
MGI:5439507
cx6
Allelic
Composition		 Ccm2ltm1Mlkn/Ccm2ltm1Mlkn
Heg1tm1Mlkn/Heg1tm1Mlkn
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2ltm1Mlkn mutation (0 available); any Ccm2l mutation (14 available)
Heg1tm1Mlkn mutation (0 available); any Heg1 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
thin myocardium ( J:187714 )
• severe myocardial thinning by E10.5
decreased ventricle muscle contractility ( J:187714 )
• marked reduction in the systolic fractional shortening of the left ventricle at E10.5

cellular

muscle
thin myocardium ( J:187714 )
• severe myocardial thinning by E10.5
decreased ventricle muscle contractility ( J:187714 )
• marked reduction in the systolic fractional shortening of the left ventricle at E10.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory