Phenotypes associated with this allele

• Allele Symbol: Fnip1^LPAB.1
• Allele Name: LPAB.1
• Allele ID: MGI:5437714
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fnip1^LPAB.1/Fnip1^LPAB.1	C57BL/6J-Fnip1^LPAB.1	MGI:5437734
cx2	Fnip1^LPAB.1/Fnip1^LPAB.1 Tg(IghMyc)22Bri/0	involves: C57BL * C57BL/6J * SJL	MGI:5437735

Genotype
MGI:5437734

hm1

• Allelic Composition: Fnip1^LPAB.1/Fnip1^LPAB.1
• Genetic Background: C57BL/6J-Fnip1^LPAB.1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

arrested B cell differentiation ( J:187318 )

• mice exhibit a cell autonomous block at the large pre-B-to-small pre-B cell transition

• antibody-mediated crosslinking of Igbeta fails to induce B cell maturation

• enforced expression of IgH, IgL or IgM fails to rescue B cell development

• B cells exhibit increased sensitivity to nutrient deprivation-induced developmental arrest compared with wild-type cells

• however, retroviral expression of Fnip1 rescues B cell development

decreased B-1 B cell number ( J:187318 )

• in the peritoneal and pleural cavities

absent B cells ( J:187318 )

• in the peripheral blood

abnormal B cell physiology ( J:187318 )

• pre-B cells exhibit decreased viability compared with wild-type cells

• however, pro-B cells exhibit normal viability and proliferation

increased B cell apoptosis ( J:187318 )

• B cells exhibit increased sensitivity to nutrient deprivation-induced apoptosis compared with wild-type cells

decreased IgE level ( J:187318 )

• mice immunized with keyhole limpet hemocyanin fail to produce

decreased IgG level ( J:187318 )

• mice immunized with keyhole limpet hemocyanin fail to produce

decreased IgG1 level ( J:187318 )

• mice immunized with keyhole limpet hemocyanin fail to produce

decreased IgG2a level ( J:187318 )

• mice immunized with keyhole limpet hemocyanin fail to produce

decreased IgM level ( J:187318 )

• mice immunized with keyhole limpet hemocyanin fail to produce

cardiovascular system

cardiomyopathy ( J:187318 )

• hypertrophic cardiomyopathy

homeostasis/metabolism

increased liver glycogen level ( J:187318 )

muscle

cardiomyopathy ( J:187318 )

• hypertrophic cardiomyopathy

abnormal skeletal muscle morphology ( J:187318 )

• deep red due to high mitochondria content

cellular

increased B cell apoptosis ( J:187318 )

• B cells exhibit increased sensitivity to nutrient deprivation-induced apoptosis compared with wild-type cells

hematopoietic system

arrested B cell differentiation ( J:187318 )

• mice exhibit a cell autonomous block at the large pre-B-to-small pre-B cell transition

• antibody-mediated crosslinking of Igbeta fails to induce B cell maturation

• enforced expression of IgH, IgL or IgM fails to rescue B cell development

• B cells exhibit increased sensitivity to nutrient deprivation-induced developmental arrest compared with wild-type cells

• however, retroviral expression of Fnip1 rescues B cell development

decreased B-1 B cell number ( J:187318 )

• in the peritoneal and pleural cavities

absent B cells ( J:187318 )

• in the peripheral blood

abnormal B cell physiology ( J:187318 )

• pre-B cells exhibit decreased viability compared with wild-type cells

• however, pro-B cells exhibit normal viability and proliferation

increased B cell apoptosis ( J:187318 )

• B cells exhibit increased sensitivity to nutrient deprivation-induced apoptosis compared with wild-type cells

decreased IgE level ( J:187318 )

• mice immunized with keyhole limpet hemocyanin fail to produce

decreased IgG level ( J:187318 )

• mice immunized with keyhole limpet hemocyanin fail to produce

decreased IgG1 level ( J:187318 )

• mice immunized with keyhole limpet hemocyanin fail to produce

decreased IgG2a level ( J:187318 )

• mice immunized with keyhole limpet hemocyanin fail to produce

decreased IgM level ( J:187318 )

• mice immunized with keyhole limpet hemocyanin fail to produce

liver/biliary system

increased liver glycogen level ( J:187318 )

Genotype
MGI:5437735

cx2

• Allelic Composition: Fnip1^LPAB.1/Fnip1^LPAB.1; Tg(IghMyc)22Bri/0
• Genetic Background: involves: C57BL * C57BL/6J * SJL

neoplasm

neoplasm ( J:187318 )

N • pre-B cell lymphomagenesis induced by c-Myc expression is inhibited

immune system

increased B cell apoptosis ( J:187318 )

• of B220+CD43+ Emu-Myc pre-B cells

cellular

increased B cell apoptosis ( J:187318 )

• of B220+CD43+ Emu-Myc pre-B cells

hematopoietic system

increased B cell apoptosis ( J:187318 )

• of B220+CD43+ Emu-Myc pre-B cells