All Phenotypes Pink1<tm1.1Wrst> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pink1^tm1.1Wrst
targeted mutation 1.1, Wolfgang Wurst
MGI:5436308

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pink1^tm1.1Wrst/Pink1^tm1.1Wrst	involves: 129S2/SvPas * BALB/cJ * C57BL/6J	MGI:5436309
cn2	Park7^Gt(XE726)Byg/Park7^Gt(XE726)Byg Pink1^tm1.1Wrst/Pink1^tm1.1Wrst Rrn3^tm1.1Igt/Rrn3^tm1.1Igt Tg(Slc6a3-cre/ERT2)1Span/0	involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J	MGI:6113544
cx3	Parl^tm1.1Bdes/Parl^tm1.1Bdes Pink1^tm1.1Wrst/Pink1^tm1.1Wrst	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:6280687
cx4	Park7^Gt(XE726)Byg/Park7^Gt(XE726)Byg Pink1^tm1.1Wrst/Pink1^tm1.1Wrst	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J	MGI:6113417
cx5	Parl^tm1.1Bdes/Parl^tm1.1Bdes Pgam5^{tm1d(EUCOMM)Wtsi}/Pgam5^{tm1d(EUCOMM)Wtsi} Pink1^tm1.1Wrst/Pink1^tm1.1Wrst	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6N	MGI:6280690
cx6	Pink1^tm1.1Wrst/Pink1^tm1.1Wrst Tg(Prnp-SNCA*A53T)AAub/?	involves: 129S2/SvPas * C57BL/6J * FVB/N	MGI:6113412
cx7	Pgam5^{tm1d(EUCOMM)Wtsi}/Pgam5^{tm1d(EUCOMM)Wtsi} Pink1^tm1.1Wrst/Pink1^tm1.1Wrst	involves: 129S2/SvPas * C57BL/6N	MGI:6280691

Allelic Composition	Pink1^tm1.1Wrst/Pink1^tm1.1Wrst
Genetic Background	involves: 129S2/SvPas * BALB/cJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pink1^tm1.1Wrst mutation (0 available); any Pink1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:183290 )

N	• no signs of dopaminergic neurodegeneration or other obvious morphological changes in the substantia nigra pars compacta or the striatum are detected • no decrease in striatal dopamine content is detected at 6 months of age

abnormal olfactory bulb glomerular layer morphology ( J:183290 )

• serotonergic innervation in the glomerular layer of the olfactory bulb is significantly decreased

abnormal innervation ( J:183290 )

• serotonergic innervation in the glomerular layer of the olfactory bulb is significantly decreased

behavior/neurological

behavior/neurological phenotype ( J:183290 )

N	• locomotor activity, anxiety related behavior, depression related behavior, and object recognition are similar to controls

abnormal gait ( J:183290 )

• decrease in the base of support for, print length of, and stand duration of the hindpaws in males at 26 months of age

• maximum contact is increased in the hindpaws in males at 26 months of age

• marked change in interpaw coordination

abnormal sensory capabilities/reflexes/nociception ( J:183290 )

• aged (27 months) males display impairments in fine olfactory discrimination abilities and olfactory sensitivity

abnormal social investigation ( J:183290 )

• young male mice, but not female mice, do not spend more time exploring a novel than a familiar conspecifc in a social discrimination task

cellular

abnormal mitochondrial morphology ( J:183290 )

• decrease in the percentage of fragmented mitochondria and increase in the percentage of intermediate mitochondria in neurons compared to wild-type controls following transduction with a lentiviral vector expressing mitochondrially targeted eYFP

taste/olfaction

abnormal olfaction ( J:183290 )

• aged (27 months) males display impairments in fine olfactory discrimination abilities and olfactory sensitivity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 6		DOID:0060369	OMIM:605909	J:183290

Allelic Composition	Park7^Gt(XE726)Byg/Park7^Gt(XE726)Byg Pink1^tm1.1Wrst/Pink1^tm1.1Wrst Rrn3^tm1.1Igt/Rrn3^tm1.1Igt Tg(Slc6a3-cre/ERT2)1Span/0
Genetic Background	involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park7^Gt(XE726)Byg mutation (1 available); any Park7 mutation (53 available)
Pink1^tm1.1Wrst mutation (0 available); any Pink1 mutation (42 available)
Rrn3^tm1.1Igt mutation (1 available); any Rrn3 mutation (41 available)
Tg(Slc6a3-cre/ERT2)1Span mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal nucleolus morphology ( J:242309 )

• nucleolar integrity is disrupted in dopaminergic neurons of tamoxifen treated mice to a similar level as seen in single conditional Rrn3 mutants

abnormal cell physiology ( J:242309 )

• induction of nucleolar stress is seen in dopaminergic neurons of tamoxifen treated mice to a similar level as seen in single conditional Rrn3 mutants

Allelic Composition	Parl^tm1.1Bdes/Parl^tm1.1Bdes Pink1^tm1.1Wrst/Pink1^tm1.1Wrst
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Parl^tm1.1Bdes mutation (1 available); any Parl mutation (28 available)
Pink1^tm1.1Wrst mutation (0 available); any Pink1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:269785 )

nervous system

neuron degeneration ( J:269785 )

Allelic Composition	Park7^Gt(XE726)Byg/Park7^Gt(XE726)Byg Pink1^tm1.1Wrst/Pink1^tm1.1Wrst
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:242309 )

N	• mice do not exhibit impaired nucleolar activity in dopaminergic neurons with unaltered rDNA transcription

Allelic Composition	Parl^tm1.1Bdes/Parl^tm1.1Bdes Pgam5^{tm1d(EUCOMM)Wtsi}/Pgam5^{tm1d(EUCOMM)Wtsi} Pink1^tm1.1Wrst/Pink1^tm1.1Wrst
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Parl^tm1.1Bdes mutation (1 available); any Parl mutation (28 available)
Pgam5^{tm1d(EUCOMM)Wtsi} mutation (0 available); any Pgam5 mutation (26 available)
Pink1^tm1.1Wrst mutation (0 available); any Pink1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:269785 )

nervous system

neuron degeneration ( J:269785 )

Allelic Composition	Pink1^tm1.1Wrst/Pink1^tm1.1Wrst Tg(Prnp-SNCA*A53T)AAub/?
Genetic Background	involves: 129S2/SvPas * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pink1^tm1.1Wrst mutation (0 available); any Pink1 mutation (42 available)
Tg(Prnp-SNCA*A53T)AAub mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:242309 )

• mice show a reduced life span

nervous system

abnormal dopaminergic neuron morphology ( J:242309 )

• nucleolar integrity is disrupted in dopaminergic neurons, with the percentage of TH+ dopaminergic neurons containing one nucleolus being lower in the substantia nigra and ventral tagmental area and an increase in the percentage of dopaminergic neurons showing no nucleolar staining

• number of dopaminergic neurons containing 2 or 3 nucleoli is higher

cellular

abnormal nucleolus morphology ( J:242309 )

• number of dopaminergic neurons containing 2 or 3 nucleoli is higher

abnormal cell physiology ( J:242309 )

• nucleolar activity is altered with downregulation in a subset of dopaminergic neurons while upregulation of rRNA synthesis is seen in another group of dopaminergic neurons suggesting initial compensatory mechanisms

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease		DOID:14330	OMIM:PS168600	J:242309

Allelic Composition	Pgam5^{tm1d(EUCOMM)Wtsi}/Pgam5^{tm1d(EUCOMM)Wtsi} Pink1^tm1.1Wrst/Pink1^tm1.1Wrst
Genetic Background	involves: 129S2/SvPas * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgam5^{tm1d(EUCOMM)Wtsi} mutation (0 available); any Pgam5 mutation (26 available)
Pink1^tm1.1Wrst mutation (0 available); any Pink1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:269785 )

N	• mice exhibit a normal lifespan

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