About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itga2tm1.1Tkun
targeted mutation 1.1, Thomas Kunicki
MGI:5433752
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Itga2tm1.1Tkun/Itga2tm1.1Tkun B6.Cg-Itga2tm1.1Tkun/J MGI:5435923
cn2
 		Itga2tm1.1Tkun/Itga2tm1.1Tkun
Tg(Pf4-icre)Q3Rsko/0 		involves: C57BL/6 * SJL MGI:5496813


Genotype
MGI:5435923
hm1
Allelic
Composition		 Itga2tm1.1Tkun/Itga2tm1.1Tkun
Genetic
Background		 B6.Cg-Itga2tm1.1Tkun/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga2tm1.1Tkun mutation (1 available); any Itga2 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:186912 )
• viable and fertile




Genotype
MGI:5496813
cn2
Allelic
Composition		 Itga2tm1.1Tkun/Itga2tm1.1Tkun
Tg(Pf4-icre)Q3Rsko/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga2tm1.1Tkun mutation (1 available); any Itga2 mutation (79 available)
Tg(Pf4-icre)Q3Rsko mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal platelet physiology ( J:195799 )
• platelets exhibit reduced adhesion and aggregation in response to soluble collagen compared with control cells
• however, tail bleeding times are normal
decreased platelet aggregation ( J:195799 )
• in response to soluble collagen

homeostasis/metabolism
abnormal platelet physiology ( J:195799 )
• platelets exhibit reduced adhesion and aggregation in response to soluble collagen compared with control cells
• however, tail bleeding times are normal
decreased platelet aggregation ( J:195799 )
• in response to soluble collagen




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory