Itga2^tm1.1Tkun
Targeted Allele Detail

Summary

• Symbol: Itga2^tm1.1Tkun
• Name: integrin alpha 2; targeted mutation 1.1, Thomas Kunicki
• MGI ID: MGI:5433752
• Synonyms: floxed-alpha2, floxed Itga2
• Gene: Itga2 Location: Chr13:114969617-115068636 bp, - strand Genetic Position: Chr13, 64.61 cM
• Alliance: Itga2^tm1.1Tkun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195799
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site-flanked targeting vector containing a FRT-flanked PGK-Neo selection cassette was utilized in the construction of this mutant. This selection cassette was inserted downstream of exon 1 of the targeted gene, and another loxP site was inserted upstream of exon 1. Flp-mediated recombination removed the neo cassette and left exon 2 floxed. (J:195799)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Itga2 Mutation: 79 strains or lines available

References

• Original: J:195799 Habart D, et al., Conditional knockout of integrin alpha2beta1 in murine megakaryocytes leads to reduced mean platelet volume. PLoS One. 2013;8(1):e55094
• All: 6 reference(s)