All Phenotypes Ugdh<tm1.1Xzh> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ugdh^tm1.1Xzh
targeted mutation 1.1, Xin Zhang
MGI:5430380

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ugdh^tm1.1Xzh/Ugdh^tm1.1Xzh	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6	MGI:5430382
cn2	Ugdh^tm1.1Xzh/Ugdh^tm1.1Xzh H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J	MGI:5430383
cn3	Kras^tm4Tyj/Kras^tm4Tyj Ugdh^tm1.1Xzh/Ugdh^tm1.1Xzh H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J	MGI:5430385
cn4	Ugdh^tm1.1Xzh/Ugdh^tm1.1Xzh H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Tg(Pax6-HRAS*G12V)2044Ove/0	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N	MGI:5430384

Allelic Composition	Ugdh^tm1.1Xzh/Ugdh^tm1.1Xzh
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ugdh^tm1.1Xzh mutation (1 available); any Ugdh mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:185652 )

• viable and fertile

Allelic Composition	Ugdh^tm1.1Xzh/Ugdh^tm1.1Xzh H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Ugdh^tm1.1Xzh mutation (1 available); any Ugdh mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:185652 )

• die at birth

endocrine/exocrine glands

abnormal lacrimal gland development ( J:185652 )

• disruption of lacrimal gland budding

absent lacrimal glands ( J:185652 )

• at E14.5 and at birth

embryo

abnormal embryonic tissue physiology ( J:185652 )

• disruption of glycosaminoglycan biosynthesis in the periocular mesenchyme

digestive/alimentary system

cleft palate ( J:185652 )

craniofacial

cleft palate ( J:185652 )

vision/eye

abnormal lacrimal gland development ( J:185652 )

• disruption of lacrimal gland budding

absent lacrimal glands ( J:185652 )

• at E14.5 and at birth

growth/size/body

cleft palate ( J:185652 )

Allelic Composition	Kras^tm4Tyj/Kras^tm4Tyj Ugdh^tm1.1Xzh/Ugdh^tm1.1Xzh H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (76 available)
Ugdh^tm1.1Xzh mutation (1 available); any Ugdh mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal lacrimal gland development ( J:185652 )

• disruption of lacrimal gland budding

absent lacrimal glands ( J:185652 )

vision/eye

abnormal lacrimal gland development ( J:185652 )

• disruption of lacrimal gland budding

absent lacrimal glands ( J:185652 )

Allelic Composition	Ugdh^tm1.1Xzh/Ugdh^tm1.1Xzh H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Tg(Pax6-HRAS*G12V)2044Ove/0
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Tg(Pax6-HRAS*G12V)2044Ove mutation (0 available)
Ugdh^tm1.1Xzh mutation (1 available); any Ugdh mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:185652 )

N	• robust lacrimal gland budding is seen unlike in mutant mice lacking Tg(Pax6-HRAS*G12V)2044Ove

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23