All Phenotypes Ugdh<tm1.1Xzh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ugdh^tm1.1Xzh
targeted mutation 1.1, Xin Zhang
MGI:5430380

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ugdh^tm1.1Xzh/Ugdh^tm1.1Xzh	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6	MGI:5430382
cn2	Ugdh^tm1.1Xzh/Ugdh^tm1.1Xzh H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J	MGI:5430383
cn3	Kras^tm4Tyj/Kras^tm4Tyj Ugdh^tm1.1Xzh/Ugdh^tm1.1Xzh H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J	MGI:5430385
cn4	Ugdh^tm1.1Xzh/Ugdh^tm1.1Xzh H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Tg(Pax6-HRAS*G12V)2044Ove/0	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N	MGI:5430384

Allelic Composition	Ugdh^tm1.1Xzh/Ugdh^tm1.1Xzh
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ugdh^tm1.1Xzh mutation (1 available); any Ugdh mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:185652 )

• viable and fertile

Allelic Composition	Ugdh^tm1.1Xzh/Ugdh^tm1.1Xzh H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (25 available)
Ugdh^tm1.1Xzh mutation (1 available); any Ugdh mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:185652 )

• die at birth

endocrine/exocrine glands

abnormal lacrimal gland development ( J:185652 )

• disruption of lacrimal gland budding

absent lacrimal glands ( J:185652 )

• at E14.5 and at birth

embryo

abnormal embryonic tissue physiology ( J:185652 )

• disruption of glycosaminoglycan biosynthesis in the periocular mesenchyme

digestive/alimentary system

cleft palate ( J:185652 )

craniofacial

cleft palate ( J:185652 )

vision/eye

abnormal lacrimal gland development ( J:185652 )

• disruption of lacrimal gland budding

absent lacrimal glands ( J:185652 )

• at E14.5 and at birth

growth/size/body

cleft palate ( J:185652 )

Allelic Composition	Kras^tm4Tyj/Kras^tm4Tyj Ugdh^tm1.1Xzh/Ugdh^tm1.1Xzh H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (25 available)
Kras^tm4Tyj mutation (11 available); any Kras mutation (69 available)
Ugdh^tm1.1Xzh mutation (1 available); any Ugdh mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal lacrimal gland development ( J:185652 )

• disruption of lacrimal gland budding

absent lacrimal glands ( J:185652 )

vision/eye

abnormal lacrimal gland development ( J:185652 )

• disruption of lacrimal gland budding

absent lacrimal glands ( J:185652 )

Allelic Composition	Ugdh^tm1.1Xzh/Ugdh^tm1.1Xzh H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Tg(Pax6-HRAS*G12V)2044Ove/0
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (25 available)
Tg(Pax6-HRAS*G12V)2044Ove mutation (0 available)
Ugdh^tm1.1Xzh mutation (1 available); any Ugdh mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:185652 )

N	• robust lacrimal gland budding is seen unlike in mutant mice lacking Tg(Pax6-HRAS*G12V)2044Ove

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