Analysis Tools
homeostasis/metabolism
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• gain more weight and more fat mass when placed on a high fat diet
• on a low fat diet body weight and fat mass are similar to wild-type
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• on a low fat diet
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• on a low fat diet
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• both at baseline and throughout an intraperitoneal glucose tolerance test
• exacerbated on a high fat diet
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• glucose intolerant
• exacerbated on a high fat diet
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cellular
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• when pyruvate is the only carbon source addition of carnitine fails to increase state 3 respiration
• rates of CO2 production are increased in isolated muscle mitochondria when exposed to moderate or high concentrations of palmitate
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• increase in whole body carbohydrate oxidation in response to an insulin challenge or during the fasting-to-fed transition is diminished
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• in isolated skeletal muscle mitochondria there is a near-complete loss of acyltransferase activity using various short chain acyl-CoA substrates
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muscle
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• marked accumulation of several medium and long chain acylcarnitines in skeletal muscle and to a lesser degree in the heart
• impaired efflux of pyruvate dehydrogenase-derived acetylcarnitine from skeletal muscle
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cardiovascular system
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• several short, medium, and long chain acyl-CoA species are elevated in the heart
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growth/size/body
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• gain more weight and more fat mass when placed on a high fat diet
• on a low fat diet body weight and fat mass are similar to wild-type
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