Analysis Tools
nervous system
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• expression of late differentiation markers in dorsal spinal neurons is reduced indicating a defect in terminal differentiation
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• almost complete loss of small diameter nociceptive fibers in the dorsal horn
• reduction in the innervation of TrkA+ and aquaporin 1+ sensory neurons in the dorsal horn
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• in dorsal spinal neurons neurites are severely reduced and remaining structures often appear misshapen
• cultured neurons from the superficial dorsal horn show a decrease in the overall number, length and branching frequency of neurites
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• almost complete loss of small diameter nociceptive fibers in the dorsal horn at E16.5
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• the superficial zone is invariably compressed and the nuclei appear compacted
• expression of late differentiation markers in dorsal spinal neurons is reduced indicating a defect in terminal differentiation
• in dorsal spinal neurons neurites are severely reduced and remaining structures often appear misshapen
• the density of DiI positive fibers is greatly reduced and the remaining fibers appear disorganized at E16.5
• almost complete loss of small diameter nociceptive fibers in the dorsal horn
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• the success rate for evoked currents is reduced in dorsal horn neurons
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cellular
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• expression of late differentiation markers in dorsal spinal neurons is reduced indicating a defect in terminal differentiation
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