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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc12a5tm2.1Tjj
targeted mutation 2.1, Thomas J Jentsch
MGI:5315721
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj
Gabra6tm2(cre)Wwis/Gabra6+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5315753
cn2
Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj
Gabra6tm2(cre)Wwis/Gabra6+
Tg(Pcp2-cre)2Mpin/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5315754
cn3
Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj
Tg(Pcp2-cre)2Mpin/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5315752


Genotype
MGI:5315753
cn1
Allelic
Composition
Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj
Gabra6tm2(cre)Wwis/Gabra6+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra6tm2(cre)Wwis mutation (2 available); any Gabra6 mutation (38 available)
Slc12a5tm2.1Tjj mutation (0 available); any Slc12a5 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit normal cerebellar histology, synaptic morphology and synaptic function
• resting membrane potential mediated by chloride ion extrusion in granule cells is disrupted compared to in wild-type mice
• chloride ion concentration is increased 2-fold compared to in wild-type mice
• spontaneous Purkinje cell firing is irregular compared to in wild-type cells

behavior/neurological
N
• mice exhibit normal short-term, gain-decreased motor learning and dark, gain consolidation
• mice exhibit impaired vestibuloocular reflex in the dark phase adjustment from day 4 (long-term memory consolidation) compared with wild-type mice




Genotype
MGI:5315754
cn2
Allelic
Composition
Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj
Gabra6tm2(cre)Wwis/Gabra6+
Tg(Pcp2-cre)2Mpin/0
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra6tm2(cre)Wwis mutation (2 available); any Gabra6 mutation (38 available)
Slc12a5tm2.1Tjj mutation (0 available); any Slc12a5 mutation (43 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit impairment in vestibuloocular reflex in the dark decrease learning and dark, gain consolidation compared with wild-type mice
• mice exhibit impaired vestibuloocular reflex in the dark phase adjustment from day 4 (long-term memory consolidation) compared with wild-type mice
• mice exhibit impairment in vestibuloocular reflex in the dark decrease learning and dark, gain consolidation compared with wild-type mice
• mice exhibit decreased gain in optokinetic reflex compared with wild-type mice
• mice exhibit a phase lag during optokinetic reflex compared with wild-type mice
• mice exhibit a phase lag during vestibuloocular reflex in the dark compared with wild-type mice
• mice exhibit impairment in vestibuloocular reflex in the dark decrease learning compared with wild-type mice
• mice exhibit a phase lag during vestibuloocular reflex in the light compared with wild-type mice

nervous system
N
• mice exhibit normal cerebellar histology, synaptic morphology and synaptic function
• mice exhibit reduced GABA-induced chloride ion currents compared with wild-type mice that is not as severe as in Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj Tg(Pcp2-cre)2Mpin mice

hearing/vestibular/ear
• mice exhibit a phase lag during vestibuloocular reflex in the dark compared with wild-type mice
• mice exhibit impairment in vestibuloocular reflex in the dark decrease learning compared with wild-type mice
• mice exhibit a phase lag during vestibuloocular reflex in the light compared with wild-type mice




Genotype
MGI:5315752
cn3
Allelic
Composition
Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj
Tg(Pcp2-cre)2Mpin/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc12a5tm2.1Tjj mutation (0 available); any Slc12a5 mutation (43 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit normal cerebellar histology, synaptic morphology and synaptic function
• chloride ion concentration is increased 2-fold compared to in wild-type mice
• GABA-induced hyperpolarization in Purkinje cells is nearly abolished compared to in wild-type cells
• regularity of Purkinje cell firing is reduced compared to in wild-type cells
• regularity of Purkinje cell firing is reduced compared to in wild-type cells
• GABA-induced hyperpolarization in Purkinje cells is nearly abolished compared to in wild-type cells

behavior/neurological
• mice exhibit impairment in vestibuloocular reflex in the dark decrease learning and dark, gain consolidation compared with wild-type mice
• in a long-term vestibuloocular reflex in the dark phase reversal training paradigm, mice are unable to reverse the phase of their eye movements unlike wild-type mice
• mice exhibit impairment in vestibuloocular reflex in the dark decrease learning and dark, gain consolidation compared with wild-type mice
• mice exhibit decreased gain in optokinetic reflex compared with wild-type mice

vision/eye
N
• mice exhibit normal retina function in vestibuloocular reflex adaptation





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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory