Phenotypes associated with this allele

• Allele Symbol: Spata22^repro42
• Allele Name: reproductive mutant 42, JAX Reproductive Mutagenesis Program
• Allele ID: MGI:5314540
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spata22^repro42/Spata22^repro42	C3.B6-Spata22^repro42	MGI:6280313
hm2	Spata22^repro42/Spata22^repro42	involves: C3HeB/FeJ * C57BL/6J	MGI:5315472
ht3	Spata22^repro42/Spata22^tm1a(KOMP)Wtsi	involves: C3H * C57BL/6N	MGI:6280314

Genotype
MGI:6280313

hm1

• Allelic Composition: Spata22^repro42/Spata22^repro42
• Genetic Background: C3.B6-Spata22^repro42

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased oocyte number ( J:249350 )

♀ • adult ovaries show severe loss of oocytes

decreased male germ cell number ( J:249350 )

♂ • adult testes show severe loss of germ cells

ovary cyst ( J:249350 )

♀ • cysts are observed in some adult ovaries

cellular

decreased oocyte number ( J:249350 )

♀ • adult ovaries show severe loss of oocytes

decreased male germ cell number ( J:249350 )

♂ • adult testes show severe loss of germ cells

endocrine/exocrine glands

ovary cyst ( J:249350 )

♀ • cysts are observed in some adult ovaries

growth/size/body

ovary cyst ( J:249350 )

♀ • cysts are observed in some adult ovaries

Genotype
MGI:5315472

hm2

• Allelic Composition: Spata22^repro42/Spata22^repro42
• Genetic Background: involves: C3HeB/FeJ * C57BL/6J

reproductive system

absent oocytes ( J:182054 )

♀

azoospermia ( J:182054 )

♂

abnormal spermatid morphology ( J:182054 )

♂ • absent

abnormal spermatocyte morphology ( J:182054 )

♂ • mice lack some stages of spermatocytes

abnormal female meiosis ( J:182054 )

♀ • meiotic arrest with impaired synapsis and DNA repair

abnormal ovarian follicle morphology ( J:182054 )

♀ • degenerating

small ovary ( J:182054 )

♀

ovary cyst ( J:182054 )

♀ • hemorrhagic cysts

decreased testis weight ( J:182054 )

♂

arrest of spermatogenesis ( J:182054 )

♂ • at stage IV

arrest of male meiosis ( J:182054 )

♂ • at prophase I with impaired synapsis and DNA repair

female infertility ( J:182054 )

♀

male infertility ( J:182054 )

♂

cellular

absent oocytes ( J:182054 )

♀

azoospermia ( J:182054 )

♂

abnormal spermatid morphology ( J:182054 )

♂ • absent

abnormal spermatocyte morphology ( J:182054 )

♂ • mice lack some stages of spermatocytes

abnormal female meiosis ( J:182054 )

♀ • meiotic arrest with impaired synapsis and DNA repair

arrest of male meiosis ( J:182054 )

♂ • at prophase I with impaired synapsis and DNA repair

abnormal double-strand DNA break repair ( J:182054 )

• impaired in oocytes and spermatocytes

endocrine/exocrine glands

abnormal ovarian follicle morphology ( J:182054 )

♀ • degenerating

small ovary ( J:182054 )

♀

ovary cyst ( J:182054 )

♀ • hemorrhagic cysts

decreased testis weight ( J:182054 )

♂

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:182054 )

• impaired in oocytes and spermatocytes

growth/size/body

ovary cyst ( J:182054 )

♀ • hemorrhagic cysts

Genotype
MGI:6280314

ht3

• Allelic Composition: Spata22^repro42/Spata22^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C3H * C57BL/6N

reproductive system

absent oocytes ( J:249350 )

♀ • adult ovaries show complete lack of oocytes

decreased male germ cell number ( J:249350 )

♂ • adult males exhibit an absence of certain spermatocytes, spermatids, and spermatozoa

azoospermia ( J:249350 )

♂

arrest of male meiosis ( J:249350 )

♂ • severe male germ cell depletion is caused by meiotic arrest

abnormal ovarian follicle morphology ( J:249350 )

♀ • adult ovaries contain degenerated follicles

small ovary ( J:249350 )

♀ • adult females exhibit smaller ovaries

ovary cyst ( J:249350 )

♀

small testis ( J:249350 )

♂ • adult males exhibit smaller testes

infertility ( J:249350 )

• both males and females are sterile but otherwise overtly normal

female infertility ( J:249350 )

♀

male infertility ( J:249350 )

♂

cellular

absent oocytes ( J:249350 )

♀ • adult ovaries show complete lack of oocytes

decreased male germ cell number ( J:249350 )

♂ • adult males exhibit an absence of certain spermatocytes, spermatids, and spermatozoa

azoospermia ( J:249350 )

♂

arrest of male meiosis ( J:249350 )

♂ • severe male germ cell depletion is caused by meiotic arrest

endocrine/exocrine glands

abnormal ovarian follicle morphology ( J:249350 )

♀ • adult ovaries contain degenerated follicles

small ovary ( J:249350 )

♀ • adult females exhibit smaller ovaries

ovary cyst ( J:249350 )

♀

small testis ( J:249350 )

♂ • adult males exhibit smaller testes

growth/size/body

ovary cyst ( J:249350 )

♀