Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation
(14 available);
any
Lyz2 mutation
(41 available)
Syktm1.1Nns mutation
(0 available);
any
Syk mutation
(42 available)
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mortality/aging
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N |
• mice exhibit normal perinatal survival
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immune system
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N |
• mice exhibit normal lymphatic vessels with normal integrity
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation
(3 available);
any
Commd10 mutation
(24 available)
Syktm1.1Nns mutation
(0 available);
any
Syk mutation
(42 available)
Tg(Tie1-cre)9Ref mutation
(2 available)
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mortality/aging
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N |
• unlike null homozygotes, mice survive to adulthood
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immune system
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• at E14.5, mice exhibit blood-filled vessels unlike wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation
(3 available);
any
Commd10 mutation
(24 available)
Syktm1.1Nns mutation
(0 available);
any
Syk mutation
(42 available)
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mortality/aging
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N |
• unlike null homozygotes, mice survive to adulthood
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immune system
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• at E14.5, mice exhibit blood-filled vessels unlike control mice
• at 8 weeks, dye injection confirms interconnection between lymphatic and blood vessels with rapid spread labeling unlike in control mice
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cardiovascular system
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• at 8 weeks, dye injection confirms interconnection between lymphatic and blood vessels with rapid spread labeling unlike in control mice
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syktm1.1Nns mutation
(0 available);
any
Syk mutation
(42 available)
Tg(CD2-icre)4Kio mutation
(4 available)
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mortality/aging
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N |
• mice exhibit normal perinatal survival
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immune system
|
N |
• mice exhibit normal lymphatic vessels
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homeostasis/metabolism
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syktm1.1Nns mutation
(0 available);
any
Syk mutation
(42 available)
Tg(Pf4-icre)Q3Rsko mutation
(1 available)
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homeostasis/metabolism
immune system
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• at E14.5, mice exhibit blood-filled vessels unlike control mice
• at 6 to 8 weeks, mice exhibit blood in mesenteric and intestinal lymphatic vessels and intestine proper unlike in control mice
• at 8 weeks, dye injection confirms interconnection between lymphatic and blood vessels with rapid spread labeling unlike in control mice
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• in the presence of platelets, reduced migration of lymphatic endothelial cells in a transmigration assay is weaker compared to in the presence of control platelets
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cardiovascular system
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• at 8 weeks, dye injection confirms interconnection between lymphatic and blood vessels with rapid spread labeling unlike in control mice
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• brain hemorrhages at E12.5
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respiratory system
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N |
• at P0, mice exhibit normal lungs
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hematopoietic system
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• in the presence of platelets, reduced migration of lymphatic endothelial cells in a transmigration assay is weaker compared to in the presence of control platelets
• platelet disruption of human lymphatic endothelial cells network formation on a matrix is disrupted to a lesser extent compared to when control platelets are used
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nervous system
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• brain hemorrhages at E12.5
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Analysis Tools