Phenotypes associated with this allele

• Allele Symbol: Vwf^tm1.1Diac
• Allele Name: targeted mutation 1.1, Thomas G Diacovo
• Allele ID: MGI:5312914
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vwf^tm1.1Diac/Vwf^tm1.1Diac	Not Specified	MGI:5312915
cx2	Itga2b^tm1Tlr/Itga2b^tm1Tlr Vwf^tm1.1Diac/Vwf^tm1.1Diac	involves: 129S1/Sv * 129X1/SvJ	MGI:5312920

Genotype
MGI:5312915

hm1

• Allelic Composition: Vwf^tm1.1Diac/Vwf^tm1.1Diac
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal platelet activation ( J:181672 )

• improved binding to human platelets

impaired blood coagulation ( J:220792 )

• mice show a diminished capacity to form thrombi in laser-injured arterioles

• plasma shows impaired adhesion of wild-type platelets and an approximate 3-fold increase in translocation velocity of wild-type platelets

increased bleeding time ( J:181672 , J:220792 )

• prolonged bleeding time (greater than 10 minutes) when th3 distal 5 mm of tail is removed (J:181672)

• mice show prolonged tail bleeding times (J:220792)

hematopoietic system

abnormal platelet activation ( J:181672 )

• improved binding to human platelets

Genotype
MGI:5312920

cx2

• Allelic Composition: Itga2b^tm1Tlr/Itga2b^tm1Tlr; Vwf^tm1.1Diac/Vwf^tm1.1Diac
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:181672 )

N • form normal thrombi in response to arteriolar injury