Vwf^tm1.1Diac
Targeted Allele Detail

Summary

• Symbol: Vwf^tm1.1Diac
• Name: Von Willebrand factor; targeted mutation 1.1, Thomas G Diacovo
• MGI ID: MGI:5312914
• Synonyms: VWF^R1326H
• Gene: Vwf Location: Chr6:125529911-125663642 bp, + strand Genetic Position: Chr6, 59.32 cM
• Alliance: Vwf^tm1.1Diac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181672
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: A guanine to adenine change in exon 28 caused an arginine to histidine change (R1325H), giving rise to a phenotype similar to that found in VWF-deficient mice. In addition, a floxed neomycin selection cassette was inserted in intron 28. This selection cassette was subsequently removed by cre mediated excision. (J:181672)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vwf Mutation: 139 strains or lines available

References

• Original: J:181672 Chen J, et al., Modifying murine von Willebrand factor A1 domain for in vivo assessment of human platelet therapies. Nat Biotechnol. 2008 Jan;26(1):114-9
• All: 3 reference(s)