Analysis Tools
growth/size/body
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• mice appear normal at weaning but fail to gain weight
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hematopoietic system
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• increase in levels of circulating neutrophils
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• increase in levels of circulating lymphocytes
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• increase in levels of circulating monocytes
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• spleens show increased expression of interferon signature genes such as Ddx58 and Isg95
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• IgG deposition in the glomeruli of kidneys
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• macrophages exhibit an acute elevation of proinflammatory cytokines IL-1beta, IL-6, and IP-10, but not IL-10, in response to ingesting dying cells that is not seen in control macrophages
• however, neither bone marrow-derived macrophages nor peritoneal exudate macrophages from 52 week old mice show any defects in the engulfment of dying cells in vitro indicating normal phagocytic capacity
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homeostasis/metabolism
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• levels of CXCL1, CCL4 and CCL2 are increased in 52-week old mice
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• in 52-week old mice
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• in 52-week old mice
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• in 52-week old mice
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• in 52-week old mice
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immune system
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• increase in levels of circulating neutrophils
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• increase in levels of circulating lymphocytes
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• increase in levels of circulating monocytes
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• spleens show increased expression of interferon signature genes such as Ddx58 and Isg95
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• IgG deposition in the glomeruli of kidneys
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• macrophages exhibit an acute elevation of proinflammatory cytokines IL-1beta, IL-6, and IP-10, but not IL-10, in response to ingesting dying cells that is not seen in control macrophages
• however, neither bone marrow-derived macrophages nor peritoneal exudate macrophages from 52 week old mice show any defects in the engulfment of dying cells in vitro indicating normal phagocytic capacity
|
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• levels of CXCL1, CCL4 and CCL2 are increased in 52-week old mice
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• in 52-week old mice
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• in 52-week old mice
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• in 52-week old mice
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• in 52-week old mice
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• mice develop a systemic lupus erythematosus-like disease (SLE)
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• increase in serum levels of a broad array of antibodies against autoantigens commonly associated with SLE
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• kidneys from aged mice show endocapillary proliferative glomerulonephritis
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renal/urinary system
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• mice show indications of kidney damage and show increased functional markers of kidney injury
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• IgG and complement C1q deposition in the glomeruli of kidneys
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• kidneys from aged mice show endocapillary proliferative glomerulonephritis
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| systemic lupus erythematosus | DOID:9074 |
OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 |
J:235399 | |
