All Phenotypes Becn1<tm1Ebr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Becn1^tm1Ebr
targeted mutation 1, Edmund B Rucker III
MGI:5308732

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Becn1^tm1Ebr/Becn1⁺ Tg(MMTV-cre)1Mam/?	involves: FVB	MGI:5308737
cn2	Becn1^tm1Ebr/Becn1⁺ Tg(EIIa-cre)C5379Lmgd/?	involves: FVB/N	MGI:5308738

Allelic Composition	Becn1^tm1Ebr/Becn1⁺ Tg(MMTV-cre)1Mam/?
Genetic Background	involves: FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Becn1^tm1Ebr mutation (0 available); any Becn1 mutation (36 available)
Tg(MMTV-cre)1Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality ( J:180916 )

• only 2 of 100 neonates survive through day 1

embryonic lethality during organogenesis, incomplete penetrance ( J:180916 )

• high level of death associated with heart and brain defects at embryonic days 11.5 and 12.5

reproductive system

abnormal primordial ovarian follicle morphology ( J:180916 )

• non uniform distribution of primordial follicles

decreased primordial ovarian follicle number ( J:180916 )

• reduced number of primordial follicles

small ovary ( J:180916 )

cardiovascular system

abnormal heart development ( J:180916 )

• high level of death associated with heart defects at embryonic days 11.5 and 12.5

nervous system

abnormal brain development ( J:180916 )

• high level of death associated with brain defects at embryonic days 11.5 and 12.5

endocrine/exocrine glands