All Phenotypes Pbx1<tm1Koss> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pbx1^tm1Koss
targeted mutation 1, Matthew J Koss
MGI:5305253

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx3^tm1Mlc/Pbx3⁺ Foxg1^tm1(cre)Skm/Foxg1⁺	involves: 129P2/OlaHsd	MGI:5305924
cn2	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx3^tm1Mlc/Pbx3⁺ Tg(Tcfap2a-cre)1Will/0	involves: 129P2/OlaHsd	MGI:5305926
cn3	Pbx1^tm1Koss/Pbx1^tm1Koss Nkx2-5^tm2(cre)Rph/Nkx2-5⁺	involves: 129P2/OlaHsd * 129S1/Sv	MGI:5426980
cn4	Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd Pbx1^tm1Koss/Pbx1^tm1Koss Nkx2-5^tm2(cre)Rph/Nkx2-5⁺	involves: 129P2/OlaHsd * 129S1/Sv	MGI:5426986
cn5	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2^tm1Mlc Foxg1^tm1(cre)Skm/Foxg1⁺	involves: 129P2/OlaHsd * 129S/Sv	MGI:5305923
cn6	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ Foxg1^tm1(cre)Skm/Foxg1⁺	involves: 129P2/OlaHsd * 129S/Sv	MGI:5305855
cn7	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ Tg(Tcfap2a-cre)1Will/0	involves: 129P2/OlaHsd * 129S/Sv	MGI:5305925
cn8	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ Nkx2-5^tm2(cre)Rph/Nkx2-5⁺	involves: 129P2/OlaHsd * 129S/Sv * 129S1/Sv	MGI:5426982
cn9	Gt(ROSA)26Sor^{tm2(Wnt1/GFP)Amc}/Gt(ROSA)26Sor⁺ Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ Tg(Tcfap2a-cre)1Will/0	involves: 129P2/OlaHsd * 129S/Sv * 129X1/SvJ	MGI:5305934
cn10	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA/J	MGI:5305927

Allelic Composition	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx3^tm1Mlc/Pbx3⁺ Foxg1^tm1(cre)Skm/Foxg1⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1^tm1(cre)Skm mutation (2 available); any Foxg1 mutation (28 available)
Pbx1^tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx3^tm1Mlc mutation (0 available); any Pbx3 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

cleft upper lip ( J:178316 )

• cleft lip and/or palate

cleft palate ( J:178316 )

• cleft lip and/or palate

digestive/alimentary system

cleft palate ( J:178316 )

• cleft lip and/or palate

growth/size/body

cleft upper lip ( J:178316 )

• cleft lip and/or palate

cleft palate ( J:178316 )

• cleft lip and/or palate

Allelic Composition	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx3^tm1Mlc/Pbx3⁺ Tg(Tcfap2a-cre)1Will/0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx1^tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx3^tm1Mlc mutation (0 available); any Pbx3 mutation (35 available)
Tg(Tcfap2a-cre)1Will mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

cleft upper lip ( J:178316 )

• cleft lip and/or palate

cleft palate ( J:178316 )

• cleft lip and/or palate

digestive/alimentary system

cleft palate ( J:178316 )

• cleft lip and/or palate

growth/size/body

cleft upper lip ( J:178316 )

• cleft lip and/or palate

cleft palate ( J:178316 )

• cleft lip and/or palate

Allelic Composition	Pbx1^tm1Koss/Pbx1^tm1Koss Nkx2-5^tm2(cre)Rph/Nkx2-5⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5^tm2(cre)Rph mutation (1 available); any Nkx2-5 mutation (21 available)
Pbx1^tm1Koss mutation (0 available); any Pbx1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal spleen morphology ( J:184521 )

• hypoplastic and fragmented

abnormal spleen mesenchyme morphology ( J:184521 )

• significant decrease of mitotic mesenchymal cells in the anlagen

spleen hypoplasia ( J:184521 )

immune system

abnormal spleen morphology ( J:184521 )

• hypoplastic and fragmented

abnormal spleen mesenchyme morphology ( J:184521 )

• significant decrease of mitotic mesenchymal cells in the anlagen

spleen hypoplasia ( J:184521 )

Allelic Composition	Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd Pbx1^tm1Koss/Pbx1^tm1Koss Nkx2-5^tm2(cre)Rph/Nkx2-5⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2b^tm1Bbd mutation (1 available); any Cdkn2b mutation (7 available)
Nkx2-5^tm2(cre)Rph mutation (1 available); any Nkx2-5 mutation (21 available)
Pbx1^tm1Koss mutation (0 available); any Pbx1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal spleen morphology ( J:184521 )

• partial rescue of spleen expansion compared to mutant mice wild-type for Cdkn2b and spleens form a single compact anlage

abnormal spleen mesenchyme morphology ( J:184521 )

• significant rescue of mesenchymal proliferation compared to mutant mice wild-type for Cdkn2b

immune system

abnormal spleen morphology ( J:184521 )

• partial rescue of spleen expansion compared to mutant mice wild-type for Cdkn2b and spleens form a single compact anlage

abnormal spleen mesenchyme morphology ( J:184521 )

• significant rescue of mesenchymal proliferation compared to mutant mice wild-type for Cdkn2b

Allelic Composition	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2^tm1Mlc Foxg1^tm1(cre)Skm/Foxg1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1^tm1(cre)Skm mutation (2 available); any Foxg1 mutation (28 available)
Pbx1^tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx2^tm1Mlc mutation (0 available); any Pbx2 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

bilateral cleft upper lip ( J:178316 )

• bilateral cleft lip

cellular

decreased apoptosis ( J:178316 )

• in the nasal epithelial at E10.75

growth/size/body

bilateral cleft upper lip ( J:178316 )

• bilateral cleft lip

Allelic Composition	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ Foxg1^tm1(cre)Skm/Foxg1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1^tm1(cre)Skm mutation (2 available); any Foxg1 mutation (28 available)
Pbx1^tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx2^tm1Mlc mutation (0 available); any Pbx2 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:178316 )

craniofacial

abnormal maxillary shelf morphology ( J:178316 )

• abnormal maxillary palatal and palatine process

absent premaxilla ( J:178316 )

• the premaxillary process is absent

abnormal nasal capsule morphology ( J:178316 )

bilateral cleft upper lip ( J:178316 )

• bilateral cleft lip

cleft palate ( J:178316 )

respiratory system

abnormal nasal capsule morphology ( J:178316 )

digestive/alimentary system

abnormal maxillary shelf morphology ( J:178316 )

• abnormal maxillary palatal and palatine process

cleft palate ( J:178316 )

skeleton

abnormal maxillary shelf morphology ( J:178316 )

• abnormal maxillary palatal and palatine process

absent premaxilla ( J:178316 )

• the premaxillary process is absent

abnormal nasal capsule morphology ( J:178316 )

growth/size/body

abnormal maxillary shelf morphology ( J:178316 )

• abnormal maxillary palatal and palatine process

abnormal nasal capsule morphology ( J:178316 )

bilateral cleft upper lip ( J:178316 )

• bilateral cleft lip

cleft palate ( J:178316 )

Allelic Composition	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ Tg(Tcfap2a-cre)1Will/0
Genetic Background	involves: 129P2/OlaHsd * 129S/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx1^tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx2^tm1Mlc mutation (0 available); any Pbx2 mutation (14 available)
Tg(Tcfap2a-cre)1Will mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

cleft upper lip ( J:178316 )

• cleft lip and/or palate

cleft palate ( J:178316 )

• cleft lip and/or palate

digestive/alimentary system

cleft palate ( J:178316 )

• cleft lip and/or palate

growth/size/body

cleft upper lip ( J:178316 )

• cleft lip and/or palate

cleft palate ( J:178316 )

• cleft lip and/or palate

Allelic Composition	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ Nkx2-5^tm2(cre)Rph/Nkx2-5⁺
Genetic Background	involves: 129P2/OlaHsd * 129S/Sv * 129S1/Sv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal spleen morphology ( J:184521 )

• hypoplastic and fragmented

• more severe than in mutant mice wild-type for Pbx2

spleen hypoplasia ( J:184521 )

immune system

abnormal spleen morphology ( J:184521 )

• hypoplastic and fragmented

• more severe than in mutant mice wild-type for Pbx2

spleen hypoplasia ( J:184521 )

Allelic Composition	Gt(ROSA)26Sor^{tm2(Wnt1/GFP)Amc}/Gt(ROSA)26Sor⁺ Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ Tg(Tcfap2a-cre)1Will/0
Genetic Background	involves: 129P2/OlaHsd * 129S/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(Wnt1/GFP)Amc} mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Pbx1^tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx2^tm1Mlc mutation (0 available); any Pbx2 mutation (14 available)
Tg(Tcfap2a-cre)1Will mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

craniofacial phenotype ( J:178316 )

N	• the cleft lip phenotype observed in Pbx1^tm1.1Koss/Pbx1^tm1.1Koss Pbx2^tm1Mlc/Pbx2⁺ Tg(Tcfap2a*-cre)1Will is rescued

Allelic Composition	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Pbx1^tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx2^tm1Mlc mutation (0 available); any Pbx2 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:178316 )

craniofacial

cleft palate ( J:178316 )

nervous system

nervous system phenotype ( J:178316 )

N	• cranial neural crest cell migration and olfactory placodes are normal

digestive/alimentary system

cleft palate ( J:178316 )

growth/size/body

cleft palate ( J:178316 )

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