Phenotypes associated with this allele

• Allele Symbol: Tet2^tm1.1Mjxu
• Allele Name: targeted mutation 1.1, Mingjiang Xu
• Allele ID: MGI:5301343
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tet2^tm1.1Mjxu/Tet2^tm1.1Mjxu	involves: 129 * C57BL/6	MGI:5301345
ht2	Tet2^tm1.1Mjxu/Tet2^+	involves: 129 * C57BL/6	MGI:5301346

Genotype
MGI:5301345

hm1

• Allelic Composition: Tet2^tm1.1Mjxu/Tet2^tm1.1Mjxu
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:178415 )

• by 1 year of age, 21 of 62 mice are moribund compared with no wild-type mice

hematopoietic system

enlarged spleen ( J:178415 )

abnormal common myeloid progenitor cell morphology ( J:178415 )

• increased numbers of granulocyte and macrophage precursors (CFU-GM) in the bone marrow and spleen

myeloid hyperplasia ( J:178415 )

• 12 of 21 mice develop myelodysplastic syndrome with erythroid predominance

• 4 of 21 mice develop myeloproliferative-like myeloid leukemia

• 4 of 21 mice develop chronic myelomonocytic leukemia

• 1 of 21 mice develop myeloid leukemia with maturation

anemia ( J:178415 )

• at 1 year of age, one-third of moribund mice exhibit pale footpads suggesting anemia unlike wild-type mice

increased bone marrow cell number ( J:178415 )

• in most mice at 2 and 4 months

increased erythrocyte cell number ( J:178415 )

• in most mice at 2 and 4 months

increased hemoglobin content ( J:178415 )

• in most mice at 2 and 4 months

increased leukocyte cell number ( J:178415 )

• in most mice at 2 and 4 months

increased neutrophil cell number ( J:178415 )

• in most mice at 2 and 4 months

increased monocyte cell number ( J:178415 )

• in most mice at 2 and 4 months

increased hematopoietic stem cell number ( J:178415 )

abnormal hematopoietic stem cell physiology ( J:178415 )

• increased proliferation and altered differentiation potential in vitro

neoplasm

increased leukemia incidence ( J:178415 )

• 12 of 21 mice develop myelodysplastic syndrome with erythroid predominance

• 4 of 21 mice develop myeloproliferative-like myeloid leukemia

• 4 of 21 mice develop chronic myelomonocytic leukemia

• 1 of 21 mice develop myeloid leukemia with maturation

increased chronic myelocytic leukemia incidence ( J:178415 )

• 4 of 21 mice develop chronic myelomonocytic leukemia

immune system

enlarged spleen ( J:178415 )

myeloid hyperplasia ( J:178415 )

• 12 of 21 mice develop myelodysplastic syndrome with erythroid predominance

• 4 of 21 mice develop myeloproliferative-like myeloid leukemia

• 4 of 21 mice develop chronic myelomonocytic leukemia

• 1 of 21 mice develop myeloid leukemia with maturation

increased leukocyte cell number ( J:178415 )

• in most mice at 2 and 4 months

increased neutrophil cell number ( J:178415 )

• in most mice at 2 and 4 months

increased monocyte cell number ( J:178415 )

• in most mice at 2 and 4 months

liver/biliary system

enlarged liver ( J:178415 )

• at 2 and 4 months

• 2 to 5 times in moribund mice at 1 year of age

growth/size/body

enlarged liver ( J:178415 )

• at 2 and 4 months

• 2 to 5 times in moribund mice at 1 year of age

enlarged spleen ( J:178415 )

Genotype
MGI:5301346

ht2

• Allelic Composition: Tet2^tm1.1Mjxu/Tet2⁺
• Genetic Background: involves: 129 * C57BL/6

mortality/aging

premature death ( J:178415 )

• by 1 year of age, 5 of 66 mice are moribund compared with no wild-type mice

hematopoietic system

enlarged spleen ( J:178415 )

• in moribund mice at 1 year of age

myeloid hyperplasia ( J:178415 )

• 2 of 5 mice develop myeloproliferative-like myeloid leukemia

• 3 of 5 mice develop chronic myelomonocytic leukemia

increased leukocyte cell number ( J:178415 )

• in 2 of 24 mice

increased monocyte cell number ( J:178415 )

• in 2 of 24 mice

neoplasm

increased leukemia incidence ( J:178415 )

• 2 of 5 mice develop myeloproliferative-like myeloid leukemia

• 3 of 5 mice develop chronic myelomonocytic leukemia

increased chronic myelocytic leukemia incidence ( J:178415 )

• 3 of 5 mice develop chronic myelomonocytic leukemia

immune system

enlarged spleen ( J:178415 )

• in moribund mice at 1 year of age

myeloid hyperplasia ( J:178415 )

• 2 of 5 mice develop myeloproliferative-like myeloid leukemia

• 3 of 5 mice develop chronic myelomonocytic leukemia

increased leukocyte cell number ( J:178415 )

• in 2 of 24 mice

increased monocyte cell number ( J:178415 )

• in 2 of 24 mice

growth/size/body

enlarged spleen ( J:178415 )

• in moribund mice at 1 year of age