Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm1.1Vari mutation
(1 available);
any
Lrp5 mutation
(81 available)
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normal phenotype
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• mice develop and reproduce normally
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm1.1Vari mutation
(1 available);
any
Lrp5 mutation
(81 available)
Lrp5tm1.2Vari mutation
(0 available);
any
Lrp5 mutation
(81 available)
Twist2tm1(cre)Dor mutation
(0 available);
any
Twist2 mutation
(10 available)
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skeleton
N |
• mice exhibit relatively normal skeleton
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mortality/aging
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• mice die shortly after birth
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skeleton
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• all skeletal elements are shortened
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• mice exhibit partial bone collar
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• mice exhibit extra cartilage elements (typically 4) in the zeugopod and in some autopods
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• profound defect in ossification of the craniofacial, the rest of the axial, and the appendicular skeleton
• partial ossification of the scapula and ileum
• however, some ossification of zeugopod elements and other skeletal elements is observed
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growth/size/body
limbs/digits/tail
craniofacial