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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapttm1(Setdb1)Akba
targeted mutation 1, Schahram Akbarian
MGI:5298877
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		\Mapttm1(Setdb1)Akba/\Mapttm1(Setdb1)Akba involves: 129S7/SvEvBrd * C57BL/6J MGI:5299158
cn2
 		\Mapttm1(Setdb1)Akba/\Mapt+
\Mecp2tm1Jae/Y
\Tg(Nes-cre)1Atp/0 		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:5299159
cn3
 		\Mapttm1(Setdb1)Akba/\Mapttm1(Setdb1)Akba
\Mecp2tm1Jae/Y
\Tg(Nes-cre)1Atp/0 		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:5299160


Genotype
MGI:5299158
hm1
Allelic
Composition		 \Mapttm1(Setdb1)Akba/\Mapttm1(Setdb1)Akba
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapttm1(Setdb1)Akba mutation (0 available); any Mapt mutation (453 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:178512 )
N
• mice exhibit normal survival

behavior/neurological
behavior/neurological phenotype ( J:178512 )
N
• mice exhibit normal neurological function




Genotype
MGI:5299159
cn2
Allelic
Composition		 \Mapttm1(Setdb1)Akba/\Mapt+
\Mecp2tm1Jae/Y
\Tg(Nes-cre)1Atp/0
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapttm1(Setdb1)Akba mutation (0 available); any Mapt mutation (453 available)
Mecp2tm1Jae mutation (2 available); any Mecp2 mutation (43 available)
Tg(Nes-cre)1Atp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:178512 )
• most mice die between 8 weeks and 24 weeks of age

behavior/neurological




Genotype
MGI:5299160
cn3
Allelic
Composition		 \Mapttm1(Setdb1)Akba/\Mapttm1(Setdb1)Akba
\Mecp2tm1Jae/Y
\Tg(Nes-cre)1Atp/0
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapttm1(Setdb1)Akba mutation (0 available); any Mapt mutation (453 available)
Mecp2tm1Jae mutation (2 available); any Mecp2 mutation (43 available)
Tg(Nes-cre)1Atp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:178512 )
• most mice die between 8 weeks and 24 weeks of age

behavior/neurological




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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory