Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Jae mutation
(2 available);
any
Mecp2 mutation
(38 available)
Tg(Camk2a-Setdb1)1Akba mutation
(0 available)
Tg(Nes-cre)1Atp mutation
(0 available)
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mortality/aging
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• mice die between 8 and 40 weeks of age
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behavior/neurological
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• worse than in Mecp2tm1Jae/Y mice
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growth/size/body
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
N |
• mice exhibit normal survival
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behavior/neurological
N |
• mice exhibit normal shock-associated reactivity and memory, novelty-induced locomotion activity, and anxiety-related behaviors
(J:160826)
• mice exhibit normal neurological function
(J:178512)
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• mice exhibit increased antidepressive behavior (increased sucrose consumption in an anhedonia test and decreased despair in a forced swim test) compared with wild-type mice
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nervous system
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• medium spiny neuron excitatory postsynaptic potential is not sensitive to NR2B/Grin2b antagonist unlike wild-type neurons
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• mice exhibit accelerated NMDA current desensitization compared with wild-type mice
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