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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dppa4tm1.1Yam
targeted mutation 1.2, Shinya Yamanaka
MGI:5298640
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Dppa2tm1.2Yam/Dppa2tm1.2Yam
Dppa4tm1.1Yam/Dppa4tm1.1Yam 		involves: 129S4/SvJae * FVB/N MGI:5298644
cx2
 		Dppa2tm1.1Yam/Dppa2tm1.1Yam
Dppa4tm1.1Yam/Dppa4tm1.1Yam 		involves: 129S4/SvJae * FVB/N MGI:5298646


Genotype
MGI:5298644
cx1
Allelic
Composition		 Dppa2tm1.2Yam/Dppa2tm1.2Yam
Dppa4tm1.1Yam/Dppa4tm1.1Yam
Genetic
Background		 involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dppa2tm1.2Yam mutation (1 available); any Dppa2 mutation (27 available)
Dppa4tm1.1Yam mutation (2 available); any Dppa4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:178324 )
• slightly fewer embryos than expected are detected at E18.5
preweaning lethality, incomplete penetrance ( J:178324 )
• at weaning, only 3.3% of pups are double homozygotes

respiratory system
abnormal lung morphology ( J:178324 )
• at E18.5 the lung mesenchyme is slightly thicker compared to controls

growth/size/body
decreased birth weight ( J:178324 )
slow postnatal weight gain ( J:178324 )
• surviving mice weigh less at 5, 10 and 15 weeks of age but catch up to controls by 20 weeks of age

reproductive system
reproductive system phenotype ( J:178324 )
N
• surviving adults are fertile




Genotype
MGI:5298646
cx2
Allelic
Composition		 Dppa2tm1.1Yam/Dppa2tm1.1Yam
Dppa4tm1.1Yam/Dppa4tm1.1Yam
Genetic
Background		 involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dppa2tm1.1Yam mutation (1 available); any Dppa2 mutation (27 available)
Dppa4tm1.1Yam mutation (2 available); any Dppa4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:178324 )
• fewer than expected found at birth
• however, expected numbers are found at E18.5
preweaning lethality, incomplete penetrance ( J:178324 )
• at weaning, only 2.9% of pups are double homozygotes

respiratory system
abnormal lung morphology ( J:178324 )
• at E18.5 the lung mesenchyme is thicker compared to controls
• severity of the increase in thickness is variable
abnormal pulmonary alveolus morphology ( J:178324 )
• smaller alveolar spaces at E18.5
• severity of the decrease in size is variable

growth/size/body
decreased birth weight ( J:178324 )

reproductive system
reproductive system phenotype ( J:178324 )
N
• surviving adults are fertile




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory