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Dppa2tm1.2Yam
Targeted Allele Detail
Summary
Symbol: Dppa2tm1.2Yam
Name: developmental pluripotency associated 2; targeted mutation 1.2, Shinya Yamanaka
MGI ID: MGI:5298642
Synonyms: 15-2FRT
Gene: Dppa2  Location: Chr16:48130637-48139876 bp, + strand  Genetic Position: Chr16, 30.75 cM
Alliance: Dppa2tm1.2Yam page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178324
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT site was inserted into intron 1 and an FRT flanked hyg cassette site was inserted after the last exon via homologous recombination. This allele was originally created in tandem with Dppa4tm1Yam. These alleles are in cis to each other. Flp mediated recombination removed the hyg cassette. Elevated transcript expression, but not protein expression, was detected in the testes of mice heterozygous for this allele and Dppa4tm1.1Yam. (J:178324)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dppa2 Mutation:  27 strains or lines available
References
Original:  J:178324 Nakamura T, et al., Essential roles of ECAT15-2/Dppa2 in functional lung development. Mol Cell Biol. 2011 Nov;31(21):4366-78
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory