Dppa4^tm1.1Yam
Targeted Allele Detail

Summary

• Symbol: Dppa4^tm1.1Yam
• Name: developmental pluripotency associated 4; targeted mutation 1.2, Shinya Yamanaka
• MGI ID: MGI:5298640
• Synonyms: 15-1^-
• Gene: Dppa4 Location: Chr16:48104096-48114600 bp, + strand Genetic Position: Chr16, 30.75 cM
• Alliance: Dppa4^tm1.1Yam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178324
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was inserted into intron 1 and a loxP site was inserted after the last exon via homologous recombination. This allele was created in tandem with Dppa2^tm1Yam. These alleles are in cis to each other. Cre mediated recombination removed the neo cassette and the floxed region. (J:178324)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dppa4 Mutation: 33 strains or lines available

References

• Original: J:178324 Nakamura T, et al., Essential roles of ECAT15-2/Dppa2 in functional lung development. Mol Cell Biol. 2011 Nov;31(21):4366-78
• All: 1 reference(s)