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Targeted Allele Detail
Symbol: Dppa4tm1.1Yam
Name: developmental pluripotency associated 4; targeted mutation 1.2, Shinya Yamanaka
MGI ID: MGI:5298640
Synonyms: 15-1-
Gene: Dppa4  Location: Chr16:48104096-48114600 bp, + strand  Genetic Position: Chr16, 30.75 cM
Alliance: Dppa4tm1.1Yam page
Germline Transmission:  Earliest citation of germline transmission: J:178324
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neo cassette was inserted into intron 1 and a loxP site was inserted after the last exon via homologous recombination. This allele was created in tandem with Dppa2tm1Yam. These alleles are in cis to each other. Cre mediated recombination removed the neo cassette and the floxed region. (J:178324)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dppa4 Mutation:  41 strains or lines available
Original:  J:178324 Nakamura T, et al., Essential roles of ECAT15-2/Dppa2 in functional lung development. Mol Cell Biol. 2011 Nov;31(21):4366-78
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory