All Phenotypes Foxn1<tm1.1Cbln> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Foxn1^tm1.1Cbln
targeted mutation 1.1, C Clare Blackburn
MGI:5297717

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxn1^tm1.1Cbln/Foxn1^tm1.1Cbln	involves: 129P2/OlaHsd * C57BL/6	MGI:5297813
ht2	Foxn1^tm1.1Cbln/Foxn1⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:5297812
ht3	Foxn1^tm1.1Cbln/Foxn1^tm1Tbo	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	MGI:5297815
cn4	Foxn1^tm1.1Cbln/Foxn1^tm1Tbo Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	MGI:5297816
cn5	Foxn1^tm1.1Cbln/Foxn1⁺ Tg(Zp3-cre)3Mrt/?	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N	MGI:5297814

Allelic Composition	Foxn1^tm1.1Cbln/Foxn1^tm1.1Cbln
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1^tm1.1Cbln mutation (0 available); any Foxn1 mutation (106 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:177992 )

• severely hypoplastic but histologically normal

abnormal lymphocyte cell number ( J:177992 )

increased DN1 thymic pro-T cell number ( J:177992 )

• most DN1 cells are B cells

increased double-positive T cell number ( J:177992 )

• proportionately increased in number

decreased single-positive T cell number ( J:177992 )

• proportionately reduced in number

hematopoietic system

thymus hypoplasia ( J:177992 )

• severely hypoplastic but histologically normal

abnormal lymphocyte cell number ( J:177992 )

increased DN1 thymic pro-T cell number ( J:177992 )

• most DN1 cells are B cells

increased double-positive T cell number ( J:177992 )

• proportionately increased in number

decreased single-positive T cell number ( J:177992 )

• proportionately reduced in number

endocrine/exocrine glands

thymus hypoplasia ( J:177992 )

• severely hypoplastic but histologically normal

increased DN1 thymic pro-T cell number ( J:177992 )

• most DN1 cells are B cells

Allelic Composition	Foxn1^tm1.1Cbln/Foxn1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1^tm1.1Cbln mutation (0 available); any Foxn1 mutation (106 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hyperplasia ( J:177992 )

• due to expression of the SV40 T antigen

• 10 fold increase in thymic epithelial cells and thymocytes

• otherwise normal

• no evidence of malignant transformation

hematopoietic system

thymus hyperplasia ( J:177992 )

• due to expression of the SV40 T antigen

• 10 fold increase in thymic epithelial cells and thymocytes

• otherwise normal

• no evidence of malignant transformation

endocrine/exocrine glands

thymus hyperplasia ( J:177992 )

• due to expression of the SV40 T antigen

• 10 fold increase in thymic epithelial cells and thymocytes

• otherwise normal

• no evidence of malignant transformation

Allelic Composition	Foxn1^tm1.1Cbln/Foxn1^tm1Tbo
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

small thymus ( J:177992 )

• small alymphatic thymic rudiments

• devoid of cortical or medullary organization

• no hematopoietic colonization of the thymus

absent T cells ( J:177992 )

• lack peripheral T cells

hematopoietic system

small thymus ( J:177992 )

• small alymphatic thymic rudiments

• devoid of cortical or medullary organization

• no hematopoietic colonization of the thymus

absent T cells ( J:177992 )

• lack peripheral T cells

integument

abnormal hair growth ( J:177992 )

• sporadic hair loss after 6 weeks of age

• overtly normal hair up to 6 weeks of age

endocrine/exocrine glands

small thymus ( J:177992 )

• small alymphatic thymic rudiments

• devoid of cortical or medullary organization

• no hematopoietic colonization of the thymus

Allelic Composition	Foxn1^tm1.1Cbln/Foxn1^tm1Tbo Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1^tm1.1Cbln mutation (0 available); any Foxn1 mutation (106 available)
Foxn1^tm1Tbo mutation (0 available); any Foxn1 mutation (106 available)
Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn} mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:177992 )

N	• restoration of normal thymus if cre induction with tamoxiphen occurs before 4 months of age

Allelic Composition	Foxn1^tm1.1Cbln/Foxn1⁺ Tg(Zp3-cre)3Mrt/?
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1^tm1.1Cbln mutation (0 available); any Foxn1 mutation (106 available)
Tg(Zp3-cre)3Mrt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:177992 )

N	• normal thymus development and function

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23