All Phenotypes Foxn1<tm1.1Cbln> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Foxn1^tm1.1Cbln
targeted mutation 1.1, C Clare Blackburn
MGI:5297717

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxn1^tm1.1Cbln/Foxn1^tm1.1Cbln	involves: 129P2/OlaHsd * C57BL/6	MGI:5297813
ht2	Foxn1^tm1.1Cbln/Foxn1⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:5297812
ht3	Foxn1^tm1.1Cbln/Foxn1^tm1Tbo	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	MGI:5297815
cn4	Foxn1^tm1.1Cbln/Foxn1^tm1Tbo Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	MGI:5297816
cn5	Foxn1^tm1.1Cbln/Foxn1⁺ Tg(Zp3-cre)3Mrt/?	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N	MGI:5297814

Allelic Composition	Foxn1^tm1.1Cbln/Foxn1^tm1.1Cbln
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1^tm1.1Cbln mutation (0 available); any Foxn1 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:177992 )

• severely hypoplastic but histologically normal

abnormal lymphocyte cell number ( J:177992 )

increased DN1 thymic pro-T cell number ( J:177992 )

• most DN1 cells are B cells

increased double-positive T cell number ( J:177992 )

• proportionately increased in number

decreased single-positive T cell number ( J:177992 )

• proportionately reduced in number

hematopoietic system

thymus hypoplasia ( J:177992 )

• severely hypoplastic but histologically normal

abnormal lymphocyte cell number ( J:177992 )

increased DN1 thymic pro-T cell number ( J:177992 )

• most DN1 cells are B cells

increased double-positive T cell number ( J:177992 )

• proportionately increased in number

decreased single-positive T cell number ( J:177992 )

• proportionately reduced in number

endocrine/exocrine glands

thymus hypoplasia ( J:177992 )

• severely hypoplastic but histologically normal

increased DN1 thymic pro-T cell number ( J:177992 )

• most DN1 cells are B cells

Allelic Composition	Foxn1^tm1.1Cbln/Foxn1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1^tm1.1Cbln mutation (0 available); any Foxn1 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hyperplasia ( J:177992 )

• due to expression of the SV40 T antigen

• 10 fold increase in thymic epithelial cells and thymocytes

• otherwise normal

• no evidence of malignant transformation

hematopoietic system

thymus hyperplasia ( J:177992 )

• due to expression of the SV40 T antigen

• 10 fold increase in thymic epithelial cells and thymocytes

• otherwise normal

• no evidence of malignant transformation

endocrine/exocrine glands

thymus hyperplasia ( J:177992 )

• due to expression of the SV40 T antigen

• 10 fold increase in thymic epithelial cells and thymocytes

• otherwise normal

• no evidence of malignant transformation

Allelic Composition	Foxn1^tm1.1Cbln/Foxn1^tm1Tbo
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

small thymus ( J:177992 )

• small alymphatic thymic rudiments

• devoid of cortical or medullary organization

• no hematopoietic colonization of the thymus

absent T cells ( J:177992 )

• lack peripheral T cells

hematopoietic system

small thymus ( J:177992 )

• small alymphatic thymic rudiments

• devoid of cortical or medullary organization

• no hematopoietic colonization of the thymus

absent T cells ( J:177992 )

• lack peripheral T cells

integument

abnormal hair growth ( J:177992 )

• sporadic hair loss after 6 weeks of age

• overtly normal hair up to 6 weeks of age

endocrine/exocrine glands

small thymus ( J:177992 )

• small alymphatic thymic rudiments

• devoid of cortical or medullary organization

• no hematopoietic colonization of the thymus

Allelic Composition	Foxn1^tm1.1Cbln/Foxn1^tm1Tbo Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1^tm1.1Cbln mutation (0 available); any Foxn1 mutation (104 available)
Foxn1^tm1Tbo mutation (0 available); any Foxn1 mutation (104 available)
Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn} mutation (1 available); any Gt(ROSA)26Sor mutation (1046 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:177992 )

N	• restoration of normal thymus if cre induction with tamoxiphen occurs before 4 months of age

Allelic Composition	Foxn1^tm1.1Cbln/Foxn1⁺ Tg(Zp3-cre)3Mrt/?
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1^tm1.1Cbln mutation (0 available); any Foxn1 mutation (104 available)
Tg(Zp3-cre)3Mrt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:177992 )

N	• normal thymus development and function

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