About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Col1a1tm2(tetO-LIN28B)Gqda
targeted mutation 2, George Q Daley
MGI:5294612
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+
Foxd1tm1(GFP/cre)Amc/Foxd1+
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+ 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5638869
cn2
 		Col1a1tm2(tetO-LIN28B)Gqda/Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Wt1tm2(cre/ERT2)Wtp/Wt1+ 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5638880
cn3
 		Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Wt1tm2(cre/ERT2)Wtp/Wt1+ 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5638793
cn4
 		Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Tg(Six2-EGFP/cre)1Amc/0 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CD-1 MGI:5638867
cn5
 		Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Tg(Cdh16-cre)91Igr/0 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * ICR MGI:5638874
cx6
 		Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+ 		involves: 129S4/SvJae * C57BL/6 * CD-1 MGI:5294614
cx7
 		Col1a1tm2(tetO-LIN28B)Gqda/Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+ 		involves: 129S4/SvJae * C57BL/6 * CD-1 MGI:5294616


Genotype
MGI:5638869
cn1
Allelic
Composition		 Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+
Foxd1tm1(GFP/cre)Amc/Foxd1+
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm2(tetO-LIN28B)Gqda mutation (1 available); any Col1a1 mutation (166 available)
Foxd1tm1(GFP/cre)Amc mutation (1 available); any Foxd1 mutation (14 available)
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy mutation (5 available); any Gt(ROSA)26Sor mutation (1046 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
hydronephrosis ( J:211179 )
• mice develop hydronephrosis following doxycycline induction

neoplasm
neoplasm ( J:211179 )
N
• mice do not develop renal tumors following doxycycline induction




Genotype
MGI:5638880
cn2
Allelic
Composition		 Col1a1tm2(tetO-LIN28B)Gqda/Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Wt1tm2(cre/ERT2)Wtp/Wt1+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm2(tetO-LIN28B)Gqda mutation (1 available); any Col1a1 mutation (166 available)
Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda mutation (1 available); any Col1a1 mutation (166 available)
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy mutation (5 available); any Gt(ROSA)26Sor mutation (1046 available)
Wt1tm2(cre/ERT2)Wtp mutation (1 available); any Wt1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
small kidney ( J:211179 )
• small kidney in mice induced with doxycycline from E14.5 until the end of the experiment
• however, cap mesenchyme differentiates normally in doxycycline induced mutants




Genotype
MGI:5638793
cn3
Allelic
Composition		 Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Wt1tm2(cre/ERT2)Wtp/Wt1+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm2(tetO-LIN28B)Gqda mutation (1 available); any Col1a1 mutation (166 available)
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy mutation (5 available); any Gt(ROSA)26Sor mutation (1046 available)
Wt1tm2(cre/ERT2)Wtp mutation (1 available); any Wt1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased kidney tumor incidence ( J:211179 )
• all mice develop kidney tumors within the first 2 weeks of life following doxycycline (Dox) induction during embryonic development at E0, E14.5 or E18.5
• tumors resemble Wilms tumor
• mice treated with doxycycline at P10 do not develop tumors

renal/urinary system
kidney cyst ( J:211179 )
• mice treated with doxycycline at P10 develop cystic kidneys
increased kidney tumor incidence ( J:211179 )
• all mice develop kidney tumors within the first 2 weeks of life following doxycycline (Dox) induction during embryonic development at E0, E14.5 or E18.5
• tumors resemble Wilms tumor
• mice treated with doxycycline at P10 do not develop tumors
abnormal kidney mesenchyme morphology ( J:211179 )
• doxycycline induced mice exhibit persistent proliferation of cap mesenchyme cells in adults
• however, cap mesenchyme cells within tumors retain a differentiation capacity that recapitulates normal kidney development
delayed kidney development ( J:211179 )
• timing of kidney development is prolonged in doxycycline induced mice, with sustaining proliferation of the cap mesenchyme cells into adulthood

growth/size/body
kidney cyst ( J:211179 )
• mice treated with doxycycline at P10 develop cystic kidneys

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
nephroblastoma DOID:2154 OMIM:194070
 J:211179




Genotype
MGI:5638867
cn4
Allelic
Composition		 Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Tg(Six2-EGFP/cre)1Amc/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm2(tetO-LIN28B)Gqda mutation (1 available); any Col1a1 mutation (166 available)
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy mutation (5 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Six2-EGFP/cre)1Amc mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
kidney cyst ( J:211179 )
• mice develop cystic kidneys when transgene expression is induced with doxycycline early in embryonic development or in adult mice

neoplasm
neoplasm ( J:211179 )
N
• mice do not develop renal tumors following doxycycline induction

growth/size/body
kidney cyst ( J:211179 )
• mice develop cystic kidneys when transgene expression is induced with doxycycline early in embryonic development or in adult mice




Genotype
MGI:5638874
cn5
Allelic
Composition		 Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm2(tetO-LIN28B)Gqda mutation (1 available); any Col1a1 mutation (166 available)
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy mutation (5 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:211179 )
N
• no kidney pathology is seen in mice induced with doxycycline




Genotype
MGI:5294614
cx6
Allelic
Composition		 Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm2(tetO-LIN28B)Gqda mutation (1 available); any Col1a1 mutation (166 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (32 available); any Gt(ROSA)26Sor mutation (1046 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased susceptibility to diet-induced obesity ( J:177113 )
• following doxycycline treatment mice gain less weight when fed a high fat diet compared to wild-type mice

homeostasis/metabolism
decreased susceptibility to diet-induced obesity ( J:177113 )
• following doxycycline treatment mice gain less weight when fed a high fat diet compared to wild-type mice
hypoglycemia ( J:177113 )
• following doxycycline treatment average fasting glucose is less than 50 mg/dL
improved glucose tolerance ( J:177113 )
• following doxycycline treatment on a normal or high fat diet
increased insulin sensitivity ( J:177113 )
• following doxycycline treatment




Genotype
MGI:5294616
cx7
Allelic
Composition		 Col1a1tm2(tetO-LIN28B)Gqda/Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm2(tetO-LIN28B)Gqda mutation (1 available); any Col1a1 mutation (166 available)
Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda mutation (1 available); any Col1a1 mutation (166 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (32 available); any Gt(ROSA)26Sor mutation (1046 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:177113 )
N
• following doxycycline treatment responses in a glucose tolerance test are similar to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory