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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lmx1atm1Ics
targeted mutation 1, Mouse Clinical Institute
MGI:5287977
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lmx1atm1Ics/Lmx1atm1Ics involves: C57BL/6J MGI:5287980
cx2
 		Lmx1atm1Ics/Lmx1atm1Ics
Lmx1btm1Rjo/Lmx1btm1Rjo 		involves: 129S7/SvEvBrd * C57BL/6J MGI:5287988
cx3
 		Lmx1atm1Ics/Lmx1a+
Lmx1btm1Rjo/Lmx1b+ 		involves: 129S7/SvEvBrd * C57BL/6J MGI:5287989
cx4
 		Lmx1atm1Ics/Lmx1atm1Ics
Lmx1btm1Rjo/Lmx1b+ 		involves: 129S7/SvEvBrd * C57BL/6J MGI:5287990


Genotype
MGI:5287980
hm1
Allelic
Composition		 Lmx1atm1Ics/Lmx1atm1Ics
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1atm1Ics mutation (0 available); any Lmx1a mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:175535 )
• generation of DNs is limited to the lateral positions despite the normal size of the DN progenitor domain
decreased dopaminergic neuron number ( J:175535 )
• expression analysis indicates a decrease in the number of dopaminergic neurons (DN) in the ventral midbrain at E11.5 and E13.5
• generation of DNs is limited to the lateral positions despite the normal size of the DN progenitor domain
• modest but significant decrease in DNs persists in postnatal mice in the ventral tegmental area

cellular
abnormal neuron differentiation ( J:175535 )
• generation of DNs is limited to the lateral positions despite the normal size of the DN progenitor domain




Genotype
MGI:5287988
cx2
Allelic
Composition		 Lmx1atm1Ics/Lmx1atm1Ics
Lmx1btm1Rjo/Lmx1btm1Rjo
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1atm1Ics mutation (0 available); any Lmx1a mutation (20 available)
Lmx1btm1Rjo mutation (0 available); any Lmx1b mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality ( J:175535 )
• die before E13.5




Genotype
MGI:5287989
cx3
Allelic
Composition		 Lmx1atm1Ics/Lmx1a+
Lmx1btm1Rjo/Lmx1b+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1atm1Ics mutation (0 available); any Lmx1a mutation (20 available)
Lmx1btm1Rjo mutation (0 available); any Lmx1b mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased dopaminergic neuron number ( J:175535 )
• about a 20 - 25% reduction in the number of Nurr1- and Pitx3-expressing cells at E13.5 compared to wild-type or single heterozygous embryos




Genotype
MGI:5287990
cx4
Allelic
Composition		 Lmx1atm1Ics/Lmx1atm1Ics
Lmx1btm1Rjo/Lmx1b+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1atm1Ics mutation (0 available); any Lmx1a mutation (20 available)
Lmx1btm1Rjo mutation (0 available); any Lmx1b mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased dopaminergic neuron number ( J:175535 )
• dramatic reduction in the number of dopaminergic neurons at E13.5 compared to embryos homozygous for the Lmx1a allele alone




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory