About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Htra1tm1Ybf
targeted mutation 1, Yingbin Fu
MGI:5285550
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Htra1tm1Ybf/Htra1tm1Ybf involves: C57BL/6J MGI:5285552
cx2
 		Htra1tm1Ybf/Htra1tm1Ybf
Tg(BEST1-HTRA1)#Ybf/0 		involves: C57BL/6J MGI:5285553


Genotype
MGI:5285552
hm1
Allelic
Composition		 Htra1tm1Ybf/Htra1tm1Ybf
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htra1tm1Ybf mutation (0 available); any Htra1 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:175227 )
N
• retinal morphology is normal




Genotype
MGI:5285553
cx2
Allelic
Composition		 Htra1tm1Ybf/Htra1tm1Ybf
Tg(BEST1-HTRA1)#Ybf/0
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htra1tm1Ybf mutation (0 available); any Htra1 mutation (50 available)
Tg(BEST1-HTRA1)#Ybf mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Similar development of polypoidal choroidal vasculopathy in Htra1tm1Ybf/Htra1tm1Ybf Tg(BEST1-HTRA1)#Ybf/0 mice as in Tg(BEST1-HTRA1)#Ybf/0 mice

vision/eye
abnormal optic choroid morphology ( J:175227 )
• defects resembling polypoidal choroidal vasculopathy (PCV) are seen

cardiovascular system
aneurysm ( J:175227 )
• small hyperfluorescent dots consistent with microaneurysmal dilations are seen




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory