All Phenotypes Sox12<tm2.1Weg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sox12^tm2.1Weg
targeted mutation 2.1, Michael Wegner
MGI:5285296

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sox12^tm2.1Weg/Sox12^tm2.1Weg	involves: 129 * C57BL/6	MGI:5285383
cn2	Sox11^tm2.1Weg/Sox11^tm2.1Weg Sox12^tm2.1Weg/Sox12^tm2.1Weg Sox4^tm1Vlf/Sox4^tm1Vlf	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5285377
cx3	Sox11^tm2.2Weg/Sox11⁺ Sox12^tm2.1Weg/Sox12^tm2.1Weg Sox4^tm1.1Vlf/Sox4⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5285380
cx4	Sox11^tm2.2Weg/Sox11^tm2.2Weg Sox12^tm2.1Weg/Sox12^tm2.1Weg Sox4^tm1.1Vlf/Sox4^tm1.1Vlf	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5285381

Allelic Composition	Sox12^tm2.1Weg/Sox12^tm2.1Weg
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox12^tm2.1Weg mutation (0 available); any Sox12 mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:175338 )

• mice are viable and fertile

Allelic Composition	Sox11^tm2.1Weg/Sox11^tm2.1Weg Sox12^tm2.1Weg/Sox12^tm2.1Weg Sox4^tm1Vlf/Sox4^tm1Vlf
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm2.1Weg mutation (0 available); any Sox11 mutation (14 available)
Sox12^tm2.1Weg mutation (0 available); any Sox12 mutation (8 available)
Sox4^tm1Vlf mutation (0 available); any Sox4 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal limb mesenchyme morphology ( J:175338 )

• large increase in cell death in limb bud mesenchyme of mice transfected with a cre-expressing adenovirus without decrease in cell proliferation

embryo

abnormal limb mesenchyme morphology ( J:175338 )

• large increase in cell death in limb bud mesenchyme of mice transfected with a cre-expressing adenovirus without decrease in cell proliferation

Allelic Composition	Sox11^tm2.2Weg/Sox11⁺ Sox12^tm2.1Weg/Sox12^tm2.1Weg Sox4^tm1.1Vlf/Sox4⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm2.2Weg mutation (0 available); any Sox11 mutation (14 available)
Sox12^tm2.1Weg mutation (0 available); any Sox12 mutation (8 available)
Sox4^tm1.1Vlf mutation (0 available); any Sox4 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

persistent truncus arteriosus ( J:175338 )

double outlet right ventricle ( J:175338 )

ventricular septal defect ( J:175338 )

• incomplete ventricular septation

skeleton

abnormal cranium morphology ( J:175338 )

• hypomineralized skull

abnormal sternebra morphology ( J:175338 )

• fusion and /or deletion

• split sternal bars in all mice

sternebra fusion ( J:175338 )

abnormal vertebrae morphology ( J:175338 )

• vertebral body duplication in all mice

abnormal bone mineralization ( J:175338 )

• hypomineralized skull

craniofacial

abnormal cranium morphology ( J:175338 )

• hypomineralized skull

immune system

small spleen ( J:175338 )

• in all mice

hematopoietic system

small spleen ( J:175338 )

• in all mice

Allelic Composition	Sox11^tm2.2Weg/Sox11^tm2.2Weg Sox12^tm2.1Weg/Sox12^tm2.1Weg Sox4^tm1.1Vlf/Sox4^tm1.1Vlf
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal neural tube morphology ( J:175338 )

• thin

• more severe than in Sox4^tm1.1Vlf Sox11^tm2.2Weg double homozygotes

kinked neural tube ( J:175338 )

• more severe than in Sox4^tm1.1Vlf Sox11^tm2.2Weg double homozygotes

nervous system

abnormal neural tube morphology ( J:175338 )

• thin

• more severe than in Sox4^tm1.1Vlf Sox11^tm2.2Weg double homozygotes

kinked neural tube ( J:175338 )

• more severe than in Sox4^tm1.1Vlf Sox11^tm2.2Weg double homozygotes

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