Phenotypes associated with this allele

• Allele Symbol: Sos1^tm1.1Les
• Allele Name: targeted mutation 1.1, Lawrence E Samelson
• Allele ID: MGI:5141757
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sos1^tm1.1Les/Sos1^tm1.1Les Tg(Lck-cre)1Cwi/0	involves: 129 * C57BL/6	MGI:5141758
cn2	Rag2^tm1Fwa/Rag2^tm1Fwa Sos1^tm1.1Les/Sos1^tm1.1Les Tg(Lck-cre)1Cwi/0	involves: 129S/SvEv * C57BL/6	MGI:5141759

Genotype
MGI:5141758

cn1

• Allelic Composition: Sos1^tm1.1Les/Sos1^tm1.1Les; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:174536 )

• a 25% reduction in proliferation of both DN4 and DP thymocytes

decreased thymocyte number ( J:174536 )

• 50% reduction in total thymocyte numbers

decreased DN4 thymocyte number ( J:174536 )

• decrease in the number and percentage of DN4 cells and an increase in the DN3:DN4 ratio

decreased double-negative T cell number ( J:174536 )

• while the total number is reduced the percentage of DN cells is increased

decreased double-positive T cell number ( J:174536 )

decreased CD4-positive, alpha-beta T cell number ( J:174536 )

• decrease in the number of CD4+ thymocytes

• however, the number of peripheral CD4+ lymph node T cells is not decreased

decreased CD8-positive, alpha-beta T cell number ( J:174536 )

• decrease in the number of CD8+ thymocytes

• however, the number of peripheral CD8+ lymph node T cells is not decreased

decreased gamma-delta T cell number ( J:174536 )

• decreased by 50%

hematopoietic system

decreased T cell proliferation ( J:174536 )

• a 25% reduction in proliferation of both DN4 and DP thymocytes

decreased thymocyte number ( J:174536 )

• 50% reduction in total thymocyte numbers

decreased DN4 thymocyte number ( J:174536 )

• decrease in the number and percentage of DN4 cells and an increase in the DN3:DN4 ratio

decreased double-negative T cell number ( J:174536 )

• while the total number is reduced the percentage of DN cells is increased

decreased double-positive T cell number ( J:174536 )

decreased CD4-positive, alpha-beta T cell number ( J:174536 )

• decrease in the number of CD4+ thymocytes

• however, the number of peripheral CD4+ lymph node T cells is not decreased

decreased CD8-positive, alpha-beta T cell number ( J:174536 )

• decrease in the number of CD8+ thymocytes

• however, the number of peripheral CD8+ lymph node T cells is not decreased

decreased gamma-delta T cell number ( J:174536 )

• decreased by 50%

endocrine/exocrine glands

decreased thymocyte number ( J:174536 )

• 50% reduction in total thymocyte numbers

decreased DN4 thymocyte number ( J:174536 )

• decrease in the number and percentage of DN4 cells and an increase in the DN3:DN4 ratio

cellular

decreased T cell proliferation ( J:174536 )

• a 25% reduction in proliferation of both DN4 and DP thymocytes

Genotype
MGI:5141759

cn2

• Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa; Sos1^tm1.1Les/Sos1^tm1.1Les; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: 129S/SvEv * C57BL/6

immune system

decreased T cell proliferation ( J:174536 )

• marked reduction in both proliferation and differentiation into DP cells on a per cell basis

abnormal T cell differentiation ( J:174536 )

• marked reduction in both proliferation and differentiation into DP cells on a per cell basis

hematopoietic system

decreased T cell proliferation ( J:174536 )

• marked reduction in both proliferation and differentiation into DP cells on a per cell basis

abnormal T cell differentiation ( J:174536 )

• marked reduction in both proliferation and differentiation into DP cells on a per cell basis

cellular

decreased T cell proliferation ( J:174536 )

• marked reduction in both proliferation and differentiation into DP cells on a per cell basis