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Allele Symbol Allele Name Allele ID |
Dab1tm1.1Mull targeted mutation 1.1, Ulrich Mueller MGI:5141401 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E14.5, neurons from mice electroporated with a cre-expressing vector at E12.5 fail to migrate into the cortical plate unlike neurons from control mice
• at E15.5, neurons from mice electroporated with a cre-expressing vector at E12.5 fail to exhibit translocating morphologies unlike neurons from control mice
• at P0, neurons from mice electroporated with a cre-expressing vector at E17.5 fail to migrate into the upper layers of the cortical plate unlike in neurons from control mice
• at P3, neurons from mice electroporated with a cre-expressing vector at E17.5 are restricted to below layer IV, near the top of layer V, of the cortical plate unlike in neurons from control mice
• at P8, neurons from mice electroporated with a cre-expressing vector at E17.5 are located below layer IV but above layers V-VI of the cortical plate unlike in neurons from control mice
• however, neurons from mice electroporated with a cre-expressing vector at E17.5 exhibit normal glia-dependent locomotion
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• at E14.5, neurons from mice electroporated with a cre-expressing vector at E12.5 fail to migrate into the cortical plate unlike neurons from control mice
• at E15.5, neurons from mice electroporated with a cre-expressing vector at E12.5 fail to exhibit translocating morphologies unlike neurons from control mice
• at P0, neurons from mice electroporated with a cre-expressing vector at E17.5 fail to migrate into the upper layers of the cortical plate unlike in neurons from control mice
• at P3, neurons from mice electroporated with a cre-expressing vector at E17.5 are restricted to below layer IV, near the top of layer V, of the cortical plate unlike in neurons from control mice
• at P8, neurons from mice electroporated with a cre-expressing vector at E17.5 are located below layer IV but above layers V-VI of the cortical plate unlike in neurons from control mice
• however, neurons from mice electroporated with a cre-expressing vector at E17.5 exhibit normal glia-dependent locomotion
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E16.5, neuron layers is defective compared to in control mice
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• the preplate fails to split unlike in control mice
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• at E16.5, mice lack the marginal zone unlike control mice
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• at E16.5
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• at E16.5, neuron layers is defective compared to in control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• at E16.5, neuron layers is defective compared to in control mice
|
|
• the preplate fails to split unlike in control mice
|
|
• at E16.5, mice lack the marginal zone unlike control mice
|
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• at E16.5
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• at E16.5, neuron layers is defective compared to in control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal splitting of the cortical preplate
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• late-born neurons are mislocalized deep within the cortex compared to in control mice
• however, the relative position of early-born neurons is normal
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• neocortical lamination is disrupted compared to in control mice
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• late-born neurons are mislocalized deep within the cortex compared to in control mice
• however, the relative position of early-born neurons is normal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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