Dab1^tm1.1Mull
Targeted Allele Detail

Summary

• Symbol: Dab1^tm1.1Mull
• Name: disabled 1; targeted mutation 1.1, Ulrich Mueller
• MGI ID: MGI:5141401
• Synonyms: Dab1^flox
• Gene: Dab1 Location: Chr4:103476556-104602041 bp, + strand Genetic Position: Chr4, 47.79 cM
• Alliance: Dab1^tm1.1Mull page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174747
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette and left exon 2 floxed. (J:174747)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dab1 Mutation: 77 strains or lines available

References

• Original: J:174747 Franco SJ, et al., Reelin regulates cadherin function via Dab1/Rap1 to control neuronal migration and lamination in the neocortex. Neuron. 2011 Feb 10;69(3):482-97
• All: 6 reference(s)