Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyfip2tm1(KOMP)Vlcg mutation
(0 available);
any
Cyfip2 mutation
(59 available)
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mortality/aging
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• mice are lethal before weaning age
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Allelic
Composition |
Cyfip2tm1(KOMP)Vlcg/Cyfip2+
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Genetic
Background |
involves: C57BL/6J * C57BL/6NTac |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyfip2tm1(KOMP)Vlcg mutation
(0 available);
any
Cyfip2 mutation
(59 available)
|
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behavior/neurological
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• increased transition between light and dark areas in a light-dark box assay
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nervous system
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N |
• mice exhibit normal hippocampal synaptic plasticity
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• increased number of mature spines and total protrusions in cortical neurons
• DHPG-treated cortical neurons fail to exhibit a decrease in the number of mature spines and an increased average length of dendritic protrusions unlike in wild-type cortical neurons
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyfip2tm1(KOMP)Vlcg mutation
(0 available);
any
Cyfip2 mutation
(59 available)
Fmr1tm1Cgr mutation
(5 available);
any
Fmr1 mutation
(28 available)
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behavior/neurological
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• increased transition between light and dark areas in a light-dark box assay that is more so than in single mutants with more time spent in the light area
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• aggravated compared with Fmr1tm1Cgr males
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nervous system
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• hippocampal neurons exhibit increased density of think (immature) spines compared with wild-type neurons to the same extent as in Fmr1tm1Cgr males
• cortical neurons exhibit increased density of think (immature) spines compared with wild-type neurons to the same a greater extent than in Fmr1tm1Cgr males
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Analysis Tools
