Cyfip2^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Cyfip2^{tm1(KOMP)Vlcg}
• Name: cytoplasmic FMR1 interacting protein 2; targeted mutation 1, Velocigene
• MGI ID: MGI:5085782
• Gene: Cyfip2 Location: Chr11:46084677-46203686 bp, - strand Genetic Position: Chr11, 27.61 cM, cytoband B1.2
• Alliance: Cyfip2^{tm1(KOMP)Vlcg} page
• IMPC: Cyfip2 gene page

Mutation origin

• Mutant Cell Lines: 18339A-G6, 18339A-H2
• Germline Transmission: Earliest citation of germline transmission: J:219363
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 30824bp between positions 46151630-46182453 of Chromosome 11 (Build GRCm39). The lacZ cassette replaced exons 2-5. QRT-PCR confirmed a 50% reduction in transcript expression in the hippocampus and cortex of heterozygotes. (J:136110, J:219363)

Expression

In Mice Carrying this Mutation:

1 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Cyfip2 Mutation: 59 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 7 reference(s)