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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm2(OVA/EGFP)Dwir
targeted mutation 2, Dagmar Wirth
MGI:5056498
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm2(OVA/EGFP)Dwir/Gt(ROSA)26Sor+
Albtm1(cre/ERT2)Mtz/Alb+ 		involves: 129P2/OlaHsd * 129S2/SvPas MGI:5056503
cn2
 		Gt(ROSA)26Sortm2(OVA/EGFP)Dwir/Gt(ROSA)26Sor+
Tg(TcraTcrb)1100Mjb/0
Albtm1(cre/ERT2)Mtz/Alb+ 		involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:5056505


Genotype
MGI:5056503
cn1
Allelic
Composition		 Gt(ROSA)26Sortm2(OVA/EGFP)Dwir/Gt(ROSA)26Sor+
Albtm1(cre/ERT2)Mtz/Alb+
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Albtm1(cre/ERT2)Mtz mutation (1 available); any Alb mutation (91 available)
Gt(ROSA)26Sortm2(OVA/EGFP)Dwir mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
abnormal hepatocyte physiology ( J:173806 )
• hepatocytes from tamoxifen-treated mice are capable of activating OT-I CD8+ T cells unlike cells from un-induced mice




Genotype
MGI:5056505
cn2
Allelic
Composition		 Gt(ROSA)26Sortm2(OVA/EGFP)Dwir/Gt(ROSA)26Sor+
Tg(TcraTcrb)1100Mjb/0
Albtm1(cre/ERT2)Mtz/Alb+
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Albtm1(cre/ERT2)Mtz mutation (1 available); any Alb mutation (91 available)
Gt(ROSA)26Sortm2(OVA/EGFP)Dwir mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating alanine transaminase level ( J:173806 )
• tamoxifen-treated mice exhibit increased serum alanine transaminase levels compared with un-induced mice
• however, un-induced mice exhibit normal alanine transaminase levels




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory