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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd1d1tm1.1Aben
targeted mutation 1.1, Albert Bendelac
MGI:5056283
Summary 4 genotypes


Genotype
MGI:5318544
cn1
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Cd1d1tm1.1Aben/Cd1d1tm1.1Aben
Genetic
Background		 B6.Cg-Cd1d1tm1.1Aben Cd19tm1(cre)Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Cd1d1tm1.1Aben mutation (1 available); any Cd1d1 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:183087 )
N
• mice exhibit normal development, distribution and activation of NK T cells




Genotype
MGI:5318545
cn2
Allelic
Composition		 Cd1d1tm1.1Aben/Cd1d1tm1.1Aben
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 B6.Cg-Cd1d1tm1.1Aben Lyz2tm1(cre)Ifo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1.1Aben mutation (1 available); any Cd1d1 mutation (30 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:183087 )
N
• mice exhibit normal development and distribution of NK T cells
decreased interferon-gamma secretion ( J:183087 )
• decreased in splenic and liver NK cells after injection of alphaGC
• decreased in splenic NK T cells after injection of alphaGC
decreased interleukin-4 secretion ( J:183087 )
• decreased in splenic and liver NK T cells after injection of alphaGC




Genotype
MGI:5318546
cn3
Allelic
Composition		 Cd1d1tm1.1Aben/Cd1d1tm1.1Aben
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 B6.Cg-Cd1d1tm1.1Aben Tg(Cd4-cre)1Cwi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1.1Aben mutation (1 available); any Cd1d1 mutation (30 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased NK T cell number ( J:183087 )
• in the thymus, spleen and liver

immune system
decreased NK T cell number ( J:183087 )
• in the thymus, spleen and liver




Genotype
MGI:5318548
cn4
Allelic
Composition		 Cd1d1tm1.1Aben/Cd1d1tm1.1Aben
Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic
Background		 C57BL/6-Cd1d1tm1.1Aben Tg(Itgax-cre,-EGFP)4097Ach
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1.1Aben mutation (1 available); any Cd1d1 mutation (30 available)
Tg(Itgax-cre,-EGFP)4097Ach mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:183087 )
N
• mice exhibit normal development and distribution of NK T cells
decreased interferon-gamma secretion ( J:183087 )
• decreased in splenic and liver NK T cells after injection of alphaGC
• absent in splenic and liver NK cells after injection of alphaGC
decreased interleukin-4 secretion ( J:183087 )
• decreased in splenic and liver NK T cells after injection of alphaGC




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory