Phenotypes associated with this allele

• Allele Symbol: Cd209b^tm1.1Cfg
• Allele Name: targeted mutation 1.1, Consortium for Functional Glycomics
• Allele ID: MGI:5052161
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd209b^tm1.1Cfg/Cd209b^tm1.1Cfg	involves: C57BL/6	MGI:5615605
hm2	Cd209b^tm1.1Cfg/Cd209b^tm1.1Cfg	involves: C57BL/6 * C57BL/6J	MGI:4366044

Genotype
MGI:5615605

hm1

• Allelic Composition: Cd209b^tm1.1Cfg/Cd209b^tm1.1Cfg
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired macrophage phagocytosis ( J:288225 )

• peritoneal macrophages exhibit reduced phagocytosis of uropathogenic Escherichia coli

increased eosinophil cell number ( J:288225 )

• uropathogenic Escherichia coli-infected mice show higher polymorphonuclear leukocyte levels in the urine

decreased mature B cell number ( J:217719 )

• lower frequency in the bone marrow

increased macrophage cell number ( J:217719 )

• greater percentage in the peritoneum after thioglycollate stimulation

increased IgG2b level ( J:217719 )

• in the T-independent assay

increased IgG3 level ( J:217719 )

• in the T-independent assay

increased IgM level ( J:217719 )

• in the T-independent assay

urinary bladder inflammation ( J:288225 )

• uropathogenic Escherichia coli-infected mice show increased susceptibility to cystitis, with more severe inflammatory lesions with abundant neutrophil infiltration

increased susceptibility to bacterial infection ( J:288225 )

• mice are more susceptible to infection with uropathogenic Escherichia coli cystitis isolate UT189, showing higher bacterial burden in the bladder at 24 hours post-infection, higher bacterial titers in urine by day 5 of infection, and prolonged bacterial persistence

• uropathogenic Escherichia coli-infected mice show more severe inflammatory lesions with abundant neutrophil infiltration and crypt abscess in bladder tissue, urothelial hyperplasia and remodeling

• however, uropathogenic Escherichia coli-infected mice show no difference in cytokine production in bladders and mice show decreased dissemination of bacteria to spleen and liver

renal/urinary system

urinary bladder inflammation ( J:288225 )

• uropathogenic Escherichia coli-infected mice show increased susceptibility to cystitis, with more severe inflammatory lesions with abundant neutrophil infiltration

abnormal glomerular mesangium morphology ( J:217719 )

• thickened

homeostasis/metabolism

decreased circulating bilirubin level ( J:217719 )

hematopoietic system

impaired macrophage phagocytosis ( J:288225 )

• peritoneal macrophages exhibit reduced phagocytosis of uropathogenic Escherichia coli

increased eosinophil cell number ( J:288225 )

• uropathogenic Escherichia coli-infected mice show higher polymorphonuclear leukocyte levels in the urine

decreased mature B cell number ( J:217719 )

• lower frequency in the bone marrow

increased macrophage cell number ( J:217719 )

• greater percentage in the peritoneum after thioglycollate stimulation

increased IgG2b level ( J:217719 )

• in the T-independent assay

increased IgG3 level ( J:217719 )

• in the T-independent assay

increased IgM level ( J:217719 )

• in the T-independent assay

cellular

impaired macrophage phagocytosis ( J:288225 )

• peritoneal macrophages exhibit reduced phagocytosis of uropathogenic Escherichia coli

Genotype
MGI:4366044

hm2

• Allelic Composition: Cd209b^tm1.1Cfg/Cd209b^tm1.1Cfg
• Genetic Background: involves: C57BL/6 * C57BL/6J

immune system

immune system phenotype ( J:153503 )

N • mice exhibit normal response to M. tuberculosis infection