Phenotypes associated with this allele

• Allele Symbol: Pml^{tm1(PML/RARA)Ley}
• Allele Name: targeted mutation 1, Timothy J Ley
• Allele ID: MGI:5014059
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Pml^tm1(PML/RARA)Ley/Pml^+	involves: C57BL/6	MGI:5014084
cn2	Pml^tm1(PML/RARA)Ley/Pml^+ Lyz2^tm1(cre)Ifo/Lyz2^+	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6	MGI:5014088
cn3	Pml^tm1(PML/RARA)Ley/Pml^+ Tg(CMV-cre)1Cgn/0	involves: BALB/cJ * C57BL/6	MGI:5014086
cn4	Pml^tm1(PML/RARA)Ley/Pml^+ Tg(CAG-cre/Esr1*)5Amc/0	involves: BALB/cJ * C57BL/6 * CBA	MGI:5014087
cn5	Pml^tm1(PML/RARA)Ley/Pml^+ Tg(Mx1-cre)1Cgn/0	involves: C57BL/6 * CBA	MGI:5014085

Genotype
MGI:5014084

ht1

• Allelic Composition: Pml^{tm1(PML/RARA)Ley}/Pml⁺
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:172024 )

• mice are viable with normal Mendelian inheritance and normal peripheral blood cell counts

Genotype
MGI:5014088

cn2

• Allelic Composition: Pml^{tm1(PML/RARA)Ley}/Pml⁺; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

neoplasm

increased leukemia incidence ( J:172024 )

• one mouse exhibit rare leukemia with acute promyelocytic leukemia features

hematopoietic system

hematopoietic system phenotype ( J:172024 )

N • hematopoietic stem cells exhibit normal ex vivo self-renewal

Genotype
MGI:5014086

cn3

• Allelic Composition: Pml^{tm1(PML/RARA)Ley}/Pml⁺; Tg(CMV-cre)1Cgn/0
• Genetic Background: involves: BALB/cJ * C57BL/6

mortality/aging

prenatal lethality, complete penetrance ( J:172024 )

• no mice are produced

Genotype
MGI:5014087

cn4

• Allelic Composition: Pml^{tm1(PML/RARA)Ley}/Pml⁺; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: BALB/cJ * C57BL/6 * CBA

hematopoietic system

enlarged spleen ( J:172024 )

• in one tamoxifen-treated mouse

decreased hematopoietic stem cell number ( J:172024 )

• small decrease in tamoxifen-treated mice

abnormal hematopoietic stem cell physiology ( J:172024 )

• hematopoietic stem cells from tamoxifen-treated mice exhibit in vitro self-renewal compared with control cells

• however, tamoxifen-treated mice do not exhibit myeloproliferative disease

immune system

enlarged spleen ( J:172024 )

• in one tamoxifen-treated mouse

growth/size/body

enlarged spleen ( J:172024 )

• in one tamoxifen-treated mouse

Genotype
MGI:5014085

cn5

• Allelic Composition: Pml^{tm1(PML/RARA)Ley}/Pml⁺; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * CBA

mortality/aging

prenatal lethality, complete penetrance ( J:172024 )

• no mice are produced