All Phenotypes Birc3<tm1.1Rbr> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Birc3^tm1.1Rbr
targeted mutation 1.1, Robert Brink
MGI:5013655

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Cd19^tm1(cre)Cgn/Cd19⁺ Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass	involves: 129P2/OlaHsd * C57BL/6 * NZB	MGI:5013718
cn2	Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * C57BL/6 * NZB	MGI:5013717
cx3	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk3^tm1Vmd/Ripk3^tm1Vmd	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL	MGI:5319384
cx4	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk3^tm1Vmd/Ripk3⁺	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL	MGI:5319381
cx5	Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Xiap^tm1Vdr/Xiap^tm1Vdr	involves: 129S1/Sv * C57BL/6 * SJL	MGI:5319377
cx6	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk1^tm1Led/Ripk1^tm1Led	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL	MGI:5319380
cx7	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk1^tm1Led/Ripk1⁺	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL	MGI:5319385
cx8	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx	involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6 * SJL	MGI:5319379
cx9	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr	involves: BALB/cJ * C57BL/6 * SJL	MGI:5319374
cx10	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx	involves: BALB/cJ * C57BL/6 * SJL	MGI:5319378
cx11	Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr	involves: C57BL/6 * NZB	MGI:5013715
cx12	Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr	involves: C57BL/6 * SJL	MGI:5319373

Allelic Composition	Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Cd19^tm1(cre)Cgn/Cd19⁺ Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * NZB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2^tm1Rbr mutation (0 available); any Birc2 mutation (33 available)
Birc3^tm1.1Rbr mutation (0 available); any Birc3 mutation (30 available)
Cd19^tm1(cre)Cgn mutation (12 available); any Cd19 mutation (62 available)
Tnfrsf13c^tm1Mass mutation (1 available); any Tnfrsf13c mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:172843 )

N	• mice exhibit normal B cell development in the spleen and lymph node unlike in Tnfrsf13c^tm1Mass homozygotes

Allelic Composition	Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * NZB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B cell apoptosis ( J:172843 )

enlarged spleen ( J:172843 )

decreased germinal center B cell number ( J:172843 )

• in response to CD40L, mice exhibit 10-fold lower germinal center B cells compared with wild-type mice

increased B cell number ( J:172843 )

• in the lymph nodes, follicular, and marginal zone

increased follicular B cell number ( J:172843 )

increased marginal zone B cell number ( J:172843 )

decreased spleen germinal center size ( J:172843 )

• in response to CD40L

enlarged lymph nodes ( J:172843 )

hematopoietic system

decreased B cell apoptosis ( J:172843 )

enlarged spleen ( J:172843 )

decreased germinal center B cell number ( J:172843 )

• in response to CD40L, mice exhibit 10-fold lower germinal center B cells compared with wild-type mice

increased B cell number ( J:172843 )

• in the lymph nodes, follicular, and marginal zone

increased follicular B cell number ( J:172843 )

increased marginal zone B cell number ( J:172843 )

decreased spleen germinal center size ( J:172843 )

• in response to CD40L

cellular

decreased B cell apoptosis ( J:172843 )

growth/size/body

enlarged spleen ( J:172843 )

Allelic Composition	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk3^tm1Vmd/Ripk3^tm1Vmd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2^tm1.1Rbr mutation (0 available); any Birc2 mutation (33 available)
Birc3^tm1.1Rbr mutation (0 available); any Birc3 mutation (30 available)
Ripk3^tm1Vmd mutation (1 available); any Ripk3 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:182515 )

• mice survive to E15.5

Allelic Composition	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk3^tm1Vmd/Ripk3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:182515 )

• mice survive to E12.5

Allelic Composition	Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Xiap^tm1Vdr/Xiap^tm1Vdr
Genetic Background	involves: 129S1/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc3^tm1.1Rbr mutation (0 available); any Birc3 mutation (30 available)
Xiap^tm1Vdr mutation (0 available); any Xiap mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:182515 )

• mice are viable and fertile and have a normal phenotype

Allelic Composition	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk1^tm1Led/Ripk1^tm1Led
Genetic Background	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2^tm1.1Rbr mutation (0 available); any Birc2 mutation (33 available)
Birc3^tm1.1Rbr mutation (0 available); any Birc3 mutation (30 available)
Ripk1^tm1Led mutation (0 available); any Ripk1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:182515 )

• mice survive to E12.5

Allelic Composition	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk1^tm1Led/Ripk1⁺
Genetic Background	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2^tm1.1Rbr mutation (0 available); any Birc2 mutation (33 available)
Birc3^tm1.1Rbr mutation (0 available); any Birc3 mutation (30 available)
Ripk1^tm1Led mutation (0 available); any Ripk1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:182515 )

• mice survive to E15.5

Allelic Composition	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx
Genetic Background	involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2^tm1.1Rbr mutation (0 available); any Birc2 mutation (33 available)
Birc3^tm1.1Rbr mutation (0 available); any Birc3 mutation (30 available)
Tnfrsf1b^tm1Imx mutation (5 available); any Tnfrsf1b mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:182515 )

• around E10.5

Allelic Composition	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr
Genetic Background	involves: BALB/cJ * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:182515 )

• around E10.5

cardiovascular system

abnormal heart atrium morphology ( J:182515 )

• sporadic discontinuities associated with pyknotic nuclei suggestive of apoptosis, usually in the atrial chamber

enlarged pericardium ( J:182515 )

• between E10.5 and E11.5, many mice exhibit swollen pericardial cavities filled with blood unlike in wild-type mice

hemorrhage ( J:182515 )

hemopericardium ( J:182515 )

• between E10.5 and E11.5

decreased cardiac muscle contractility ( J:182515 )

• between E10.5 and E11.5, mice exhibit minimal or no contractile activity unlike in wild-type mice

congestive heart failure ( J:182515 )

homeostasis/metabolism

hemopericardium ( J:182515 )

• between E10.5 and E11.5

muscle

decreased cardiac muscle contractility ( J:182515 )

• between E10.5 and E11.5, mice exhibit minimal or no contractile activity unlike in wild-type mice

Allelic Composition	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx
Genetic Background	involves: BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2^tm1.1Rbr mutation (0 available); any Birc2 mutation (33 available)
Birc3^tm1.1Rbr mutation (0 available); any Birc3 mutation (30 available)
Tnfrsf1a^tm1Imx mutation (6 available); any Tnfrsf1a mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:182515 )

• while mice are born alive none survive to weaning

Allelic Composition	Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr
Genetic Background	involves: C57BL/6 * NZB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:172843 )

N	• mice exhibit no differences in spleen or lymph node size or in the numbers or phenotype of the B cells within these peripheral lymphoid tissues compared with wild-type mice

Allelic Composition	Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr
Genetic Background	involves: C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:182515 )

• mice are viable with no reproductive or developmental defects

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24