Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2tm1Rbr mutation
(0 available);
any
Birc2 mutation
(33 available)
Birc3tm1.1Rbr mutation
(0 available);
any
Birc3 mutation
(31 available)
Cd19tm1(cre)Cgn mutation
(11 available);
any
Cd19 mutation
(56 available)
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immune system
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• in response to CD40L, mice exhibit 10-fold lower germinal center B cells compared with wild-type mice
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• in the lymph nodes, follicular, and marginal zone
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hematopoietic system
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• in response to CD40L, mice exhibit 10-fold lower germinal center B cells compared with wild-type mice
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• in the lymph nodes, follicular, and marginal zone
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cellular
growth/size/body
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2tm1Rbr mutation
(0 available);
any
Birc2 mutation
(33 available)
Birc3tm1.1Rbr mutation
(0 available);
any
Birc3 mutation
(31 available)
Cd19tm1(cre)Cgn mutation
(11 available);
any
Cd19 mutation
(56 available)
Tnfrsf13ctm1Mass mutation
(1 available);
any
Tnfrsf13c mutation
(14 available)
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immune system
N |
• mice exhibit normal B cell development in the spleen and lymph node unlike in Tnfrsf13ctm1Mass homozygotes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2tm1.1Rbr mutation
(0 available);
any
Birc2 mutation
(33 available)
Birc3tm1.1Rbr mutation
(0 available);
any
Birc3 mutation
(31 available)
Ripk3tm1Vmd mutation
(1 available);
any
Ripk3 mutation
(31 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2tm1.1Rbr mutation
(0 available);
any
Birc2 mutation
(33 available)
Birc3tm1.1Rbr mutation
(0 available);
any
Birc3 mutation
(31 available)
Ripk3tm1Vmd mutation
(1 available);
any
Ripk3 mutation
(31 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc3tm1.1Rbr mutation
(0 available);
any
Birc3 mutation
(31 available)
Xiaptm1Vdr mutation
(0 available);
any
Xiap mutation
(37 available)
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normal phenotype
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• mice are viable and fertile and have a normal phenotype
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2tm1.1Rbr mutation
(0 available);
any
Birc2 mutation
(33 available)
Birc3tm1.1Rbr mutation
(0 available);
any
Birc3 mutation
(31 available)
Ripk1tm1Led mutation
(0 available);
any
Ripk1 mutation
(31 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2tm1.1Rbr mutation
(0 available);
any
Birc2 mutation
(33 available)
Birc3tm1.1Rbr mutation
(0 available);
any
Birc3 mutation
(31 available)
Ripk1tm1Led mutation
(0 available);
any
Ripk1 mutation
(31 available)
|
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2tm1.1Rbr mutation
(0 available);
any
Birc2 mutation
(33 available)
Birc3tm1.1Rbr mutation
(0 available);
any
Birc3 mutation
(31 available)
Tnfrsf1btm1Imx mutation
(5 available);
any
Tnfrsf1b mutation
(41 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2tm1.1Rbr mutation
(0 available);
any
Birc2 mutation
(33 available)
Birc3tm1.1Rbr mutation
(0 available);
any
Birc3 mutation
(31 available)
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mortality/aging
cardiovascular system
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• sporadic discontinuities associated with pyknotic nuclei suggestive of apoptosis, usually in the atrial chamber
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• between E10.5 and E11.5, many mice exhibit swollen pericardial cavities filled with blood unlike in wild-type mice
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• between E10.5 and E11.5
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• between E10.5 and E11.5, mice exhibit minimal or no contractile activity unlike in wild-type mice
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homeostasis/metabolism
muscle
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• between E10.5 and E11.5, mice exhibit minimal or no contractile activity unlike in wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2tm1.1Rbr mutation
(0 available);
any
Birc2 mutation
(33 available)
Birc3tm1.1Rbr mutation
(0 available);
any
Birc3 mutation
(31 available)
Tnfrsf1atm1Imx mutation
(6 available);
any
Tnfrsf1a mutation
(47 available)
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mortality/aging
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• while mice are born alive none survive to weaning
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2tm1Rbr mutation
(0 available);
any
Birc2 mutation
(33 available)
Birc3tm1.1Rbr mutation
(0 available);
any
Birc3 mutation
(31 available)
|
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immune system
N |
• mice exhibit no differences in spleen or lymph node size or in the numbers or phenotype of the B cells within these peripheral lymphoid tissues compared with wild-type mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2tm1Rbr mutation
(0 available);
any
Birc2 mutation
(33 available)
Birc3tm1.1Rbr mutation
(0 available);
any
Birc3 mutation
(31 available)
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normal phenotype
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• mice are viable with no reproductive or developmental defects
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