Phenotypes associated with this allele

• Allele Symbol: Id3^tm2.1Zhu
• Allele Name: targeted mutation 2.1, Yuan Zhuang
• Allele ID: MGI:5009711
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^+ Id3^tm2.1Zhu/Id3^tm2.1Zhu Tg(Lck-cre)#Zhu/0	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL	MGI:5009806
cn2	Id3^tm2.1Zhu/Id3^tm2.1Zhu Tg(Lck-cre)#Zhu/0	involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J	MGI:5009805

Genotype
MGI:5009806

cn1

• Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺; Id3^tm2.1Zhu/Id3^tm2.1Zhu; Tg(Lck-cre)#Zhu/0
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell number ( J:172701 )

• in lymph node, parotid salivary gland, submandibular gland, and lacrimal gland

hematopoietic system

decreased T cell number ( J:172701 )

• in lymph node, parotid salivary gland, submandibular gland, and lacrimal gland

Genotype
MGI:5009805

cn2

• Allelic Composition: Id3^tm2.1Zhu/Id3^tm2.1Zhu; Tg(Lck-cre)#Zhu/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J

immune system

parotid gland inflammation ( J:172701 )

• between 8 and 12 months

submandibular gland inflammation ( J:172701 )

• between 8 and 12 months

abnormal T cell differentiation ( J:172701 )

• as detected by marker expression, T cell development from the double positive to single positive stage is delayed compared to in wild-type mice

• however, single positive cells are able to enter the medulla

increased CD4-positive, alpha-beta memory T cell number ( J:172701 )

• slightly and unchanged by age

increased CD8-positive, alpha-beta memory T cell number ( J:172701 )

• slightly and unchanged by age

increased gamma-delta T cell number ( J:172701 )

• in the thymus

decreased T cell number ( J:172701 )

• the number of mature alpha-beta T cells in the thymus is decreased compared to in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:172701 )

• in the thymus

• in the spleen of young mice

• however, numbers are normal in aged mice

decreased CD8-positive, alpha-beta T cell number ( J:172701 )

• in the thymus

• in the spleen of young mice

• however, numbers are normal in aged mice

digestive/alimentary system

parotid gland inflammation ( J:172701 )

• between 8 and 12 months

submandibular gland inflammation ( J:172701 )

• between 8 and 12 months

decreased salivation ( J:172701 )

• after pilocarpine stimulation

endocrine/exocrine glands

parotid gland inflammation ( J:172701 )

• between 8 and 12 months

submandibular gland inflammation ( J:172701 )

• between 8 and 12 months

decreased salivation ( J:172701 )

• after pilocarpine stimulation

hematopoietic system

abnormal T cell differentiation ( J:172701 )

• as detected by marker expression, T cell development from the double positive to single positive stage is delayed compared to in wild-type mice

• however, single positive cells are able to enter the medulla

increased CD4-positive, alpha-beta memory T cell number ( J:172701 )

• slightly and unchanged by age

increased CD8-positive, alpha-beta memory T cell number ( J:172701 )

• slightly and unchanged by age

increased gamma-delta T cell number ( J:172701 )

• in the thymus

decreased T cell number ( J:172701 )

• the number of mature alpha-beta T cells in the thymus is decreased compared to in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:172701 )

• in the thymus

• in the spleen of young mice

• however, numbers are normal in aged mice

decreased CD8-positive, alpha-beta T cell number ( J:172701 )

• in the thymus

• in the spleen of young mice

• however, numbers are normal in aged mice

homeostasis/metabolism

decreased salivation ( J:172701 )

• after pilocarpine stimulation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Sjogren's syndrome		DOID:12894	OMIM:270150	J:172701