About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atg3tm1.1Ywh
targeted mutation 1.1, You-Wen He
MGI:5009305
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Atg3tm1.1Ywh/Atg3tm1.1Ywh
Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJaeSor * C57BL/6 MGI:5009307
cn2
 		Atg3tm1.1Ywh/Atg3tm1.1Ywh
Fnip1m1Btlr/Fnip1m1Btlr
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+ 		involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5806734
cn3
 		Atg3tm1.1Ywh/Atg3tm1.1Ywh
Tg(Lck-cre)548Jxm/0 		involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * CBA MGI:5009306


Genotype
MGI:5009307
cn1
Allelic
Composition		 Atg3tm1.1Ywh/Atg3tm1.1Ywh
Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg3tm1.1Ywh mutation (0 available); any Atg3 mutation (19 available)
Gt(ROSA)26Sortm1(cre/ERT)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell apoptosis ( J:172749 )
• following tamoxifen stimulation
• however, apoptosis is rescued by IL7 treatment
abnormal T cell morphology ( J:172749 )
• T lymphocytes exhibit increased mitochondria and endoplasmic reticulum content compared with wild-type cells

hematopoietic system
increased T cell apoptosis ( J:172749 )
• following tamoxifen stimulation
• however, apoptosis is rescued by IL7 treatment
abnormal T cell morphology ( J:172749 )
• T lymphocytes exhibit increased mitochondria and endoplasmic reticulum content compared with wild-type cells

cellular
increased T cell apoptosis ( J:172749 )
• following tamoxifen stimulation
• however, apoptosis is rescued by IL7 treatment




Genotype
MGI:5806734
cn2
Allelic
Composition		 Atg3tm1.1Ywh/Atg3tm1.1Ywh
Fnip1m1Btlr/Fnip1m1Btlr
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg3tm1.1Ywh mutation (0 available); any Atg3 mutation (19 available)
Fnip1m1Btlr mutation (0 available); any Fnip1 mutation (59 available)
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (3 available); any Gt(ROSA)26Sor mutation (942 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
absent B cells ( J:234285 )
• in the spleen and bone marrow B cell subsets of tamoxifen-treated mice

cellular
abnormal autophagy ( J:234285 )
• tamoxifen-treated B cell precursors fail to exhibit an increase in bafilomycin-induced autophagy unlike in control cells

hematopoietic system
absent B cells ( J:234285 )
• in the spleen and bone marrow B cell subsets of tamoxifen-treated mice

homeostasis/metabolism
abnormal autophagy ( J:234285 )
• tamoxifen-treated B cell precursors fail to exhibit an increase in bafilomycin-induced autophagy unlike in control cells




Genotype
MGI:5009306
cn3
Allelic
Composition		 Atg3tm1.1Ywh/Atg3tm1.1Ywh
Tg(Lck-cre)548Jxm/0
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg3tm1.1Ywh mutation (0 available); any Atg3 mutation (19 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
impaired autophagy ( J:172749 )
• T cells stimulated with anti-CD3 antibodies exhibit impaired autophagy compared with wild-type cells

immune system
increased T cell apoptosis ( J:172749 )
• in the spleen
decreased T cell proliferation ( J:172749 )
• of T cells stimulated with anti-CD3 antibodies
abnormal T cell morphology ( J:172749 )
• T lymphocytes exhibit increased mitochondria and endoplasmic reticulum content compared with wild-type cells

cellular
impaired autophagy ( J:172749 )
• T cells stimulated with anti-CD3 antibodies exhibit impaired autophagy compared with wild-type cells
increased T cell apoptosis ( J:172749 )
• in the spleen
decreased T cell proliferation ( J:172749 )
• of T cells stimulated with anti-CD3 antibodies
oxidative stress ( J:172749 )
• T cells exhibit overproduction of reactive oxygen species compared with wild-type cells

hematopoietic system
increased T cell apoptosis ( J:172749 )
• in the spleen
decreased T cell proliferation ( J:172749 )
• of T cells stimulated with anti-CD3 antibodies
abnormal T cell morphology ( J:172749 )
• T lymphocytes exhibit increased mitochondria and endoplasmic reticulum content compared with wild-type cells

endocrine/exocrine glands




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory