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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mglltm1.1Rzim
targeted mutation 1.1, Robert Zimmermann
MGI:5009247
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mglltm1.1Rzim/Mglltm1.1Rzim involves: 129P2/OlaHsd * C57BL/6 MGI:5009274


Genotype
MGI:5009274
hm1
Allelic
Composition
Mglltm1.1Rzim/Mglltm1.1Rzim
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mglltm1.1Rzim mutation (0 available); any Mgll mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• in mice treated with a high dose of CP 55,940 compared with similarly treated wild-type mice
• in mice fed a high-fat diet compared with similarly treated wild-type mice
• when fed a high-fat diet compared with similarly treated wild-type mice
• when fed a high-fat diet compared with similarly treated wild-type mice
• in fed and fasted mice
• in mice fed a high-fat diet
• in fasted mice
• in mice treated with poloxamer 407 (P407) to inhibit lipoprotein lipase activity
• in mice fed a high-fat diet
• forskolin-stimulated FA and glycerol release from white adipose tissue fat pads are decreased by compared to in wild-type mice
• modest as indicated by decreased circulating levels of glycerol, ketones, and triglycerides in a fasted state but normal circulating free fatty acid levels
• mice exhibit an increased tolerance to the hypometabolic activity (decreased locomotor activity and oxygen consumption) induced by a high dose of CP 55,940 compared with wild-type mice

behavior/neurological
• in mice treated with a high dose of CP 55,940 compared with similarly treated wild-type mice
• in mice treated with a high dose of CP 55,940 compared with similarly treated wild-type mice

growth/size/body
N
• whether fed standard chow or a high fat-diet, mice exhibit normal body weight, fat mass, and lean mass

liver/biliary system





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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory