Mgll^tm1.1Rzim
Targeted Allele Detail

Summary

• Symbol: Mgll^tm1.1Rzim
• Name: monoglyceride lipase; targeted mutation 1.1, Robert Zimmermann
• MGI ID: MGI:5009247
• Gene: Mgll Location: Chr6:88701397-88805342 bp, + strand Genetic Position: Chr6, 39.51 cM
• Alliance: Mgll^tm1.1Rzim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172679
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A floxed neo cassette was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 4. Cre-mediated recombination removed the neo cassette and exons 3 and 4. Monoacylglycerol hydrolase (MGH) activity assays confirmed the reduction in neutral MGH activity in white adipose tissue and liver and almost undetectable levels in the brain. (J:172679)

Generation of the Mgll^tm1.1Rzim allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mgll Mutation: 29 strains or lines available

References

• Original: J:172679 Taschler U, et al., Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance. J Biol Chem. 2011 May 20;286(20):17467-77
• All: 5 reference(s)