Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation
(3 available);
any
Cd79a mutation
(22 available)
Stim1tm1Kuro mutation
(0 available);
any
Stim1 mutation
(46 available)
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immune system
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• B cells exhibit less calcium ion influx after treatment with thapsigargin or anti-IgM compared with control mice
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• anti-IgM-treated B cells exhibit decreased proliferation unlike control cells
• however, B cell proliferation stimulated by anti-CD40 or LPS is normal
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• following PMA and ionomycin stimulation
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hematopoietic system
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• B cells exhibit less calcium ion influx after treatment with thapsigargin or anti-IgM compared with control mice
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• anti-IgM-treated B cells exhibit decreased proliferation unlike control cells
• however, B cell proliferation stimulated by anti-CD40 or LPS is normal
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cellular
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• anti-IgM-treated B cells exhibit decreased proliferation unlike control cells
• however, B cell proliferation stimulated by anti-CD40 or LPS is normal
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation
(3 available);
any
Cd79a mutation
(22 available)
Stim1tm1Kuro mutation
(0 available);
any
Stim1 mutation
(46 available)
Stim2tm1.1Kuro mutation
(0 available);
any
Stim2 mutation
(42 available)
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immune system
N |
• mice exhibit normal B cell development
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• following immunization with MOG35-55
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• following immunization with MOG35-55
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• following immunization with MOG35-55
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• B cells exhibit little calcium ion influx after treatment with thapsigargin or anti-IgM compared with control mice
• B cells treated with anti-IgM, anti-IgM and IL4, or anti-IgM and anti-CD40 exhibit reduced survival compared with control cells
• however, B cell treated with anti-CD40 or LPS exhibit normal survival and B cell antibody response is normal
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• B cells treated anti-IgM fail to exhibit proliferation unlike control cells
• B cells treated anti-IgM and IL4 exhibit reduced proliferation compared with control cells
• however, B cell proliferation stimulated by anti-CD40 or LPS is normal
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• in splenocytes following immunization with MOG35-55
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• following stimulation with PMA and ionomycin, LPS, anti-IgM and anti-CD40, or anti-IgM and LPS
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• in splenocytes following immunization with MOG35-55
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• in splenocytes following immunization with MOG35-55
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• following immunization with MOG35-55, mice exhibit increased inflammatory cells infiltration (CD8+ and CD4+ T cells, T regulatory cells), demyelination, and cytokine production (IFN-gamma, IL17, and IL10) compared with control mice
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nervous system
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• following immunization with MOG35-55
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hematopoietic system
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• following immunization with MOG35-55
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• following immunization with MOG35-55
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• following immunization with MOG35-55
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• B cells exhibit little calcium ion influx after treatment with thapsigargin or anti-IgM compared with control mice
• B cells treated with anti-IgM, anti-IgM and IL4, or anti-IgM and anti-CD40 exhibit reduced survival compared with control cells
• however, B cell treated with anti-CD40 or LPS exhibit normal survival and B cell antibody response is normal
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• B cells treated anti-IgM fail to exhibit proliferation unlike control cells
• B cells treated anti-IgM and IL4 exhibit reduced proliferation compared with control cells
• however, B cell proliferation stimulated by anti-CD40 or LPS is normal
|
cellular
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• B cells treated anti-IgM fail to exhibit proliferation unlike control cells
• B cells treated anti-IgM and IL4 exhibit reduced proliferation compared with control cells
• however, B cell proliferation stimulated by anti-CD40 or LPS is normal
|