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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm2(H1/tetO-RNAi:Pdpk1)Mrl
targeted mutation 2, Merck Research Laboratory
MGI:5007773
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm2(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/0 		involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:5008589


Genotype
MGI:5008589
cn1
Allelic
Composition		 Gt(ROSA)26Sortm2(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(H1/tetO-RNAi:Pdpk1)Mrl mutation (0 available); any Gt(ROSA)26Sor mutation (1058 available)
Ptentm1Hwu mutation (17 available); any Pten mutation (86 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
enlarged prostate gland anterior lobe ( J:170965 )
• in doxycycline-treated mice
increased prostate gland weight ( J:170965 )
• in doxycycline-treated mice
prostate gland hyperplasia ( J:170965 )
• in doxycycline-treated mice
increased prostate gland tumor incidence ( J:170965 )
• doxycycline-treated mice exhibit microinvasive tumors in the prostate gland unlike in Pdpk1tm1Dral homozygotes

neoplasm
increased prostate gland tumor incidence ( J:170965 )
• doxycycline-treated mice exhibit microinvasive tumors in the prostate gland unlike in Pdpk1tm1Dral homozygotes

endocrine/exocrine glands
enlarged prostate gland anterior lobe ( J:170965 )
• in doxycycline-treated mice
increased prostate gland weight ( J:170965 )
• in doxycycline-treated mice
prostate gland hyperplasia ( J:170965 )
• in doxycycline-treated mice
increased prostate gland tumor incidence ( J:170965 )
• doxycycline-treated mice exhibit microinvasive tumors in the prostate gland unlike in Pdpk1tm1Dral homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory