Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Pdpk1tm1Dral
Name:	3-phosphoinositide dependent protein kinase 1; targeted mutation 1, Dario R Alessi
MGI ID:	MGI:3795190
Synonyms:	PDK1K465E
Gene:	Pdpk1  Location: Chr17:24292654-24369898 bp, - strand  Genetic Position: Chr17, 12.23 cM, cytoband A3.3
Alliance:	Pdpk1tm1Dral page

Germline Transmission:	Earliest citation of germline transmission: J:136089
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Not Applicable) Mutations:    Insertion, Nucleotide substitutions   Mutation details: Exon 12 wass replaced with a floxed neo cassette and an exon 12 containing a nucleotide substitution that results in the amino acid substitution of glutamic acid for lysine at position 465 (K465E). The neo cassette was removed by germ line, cre-mediated recombination. (J:136089)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	42 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

List all tumor models in MMHCdb carrying Pdpk1tm1Dral

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdpk1 Mutation:	138 strains or lines available

Original:	J:136089 Bayascas JR, et al., Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance. Mol Cell Biol. 2008 May;28(10):3258-72
All:	8 reference(s)