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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cul4atm1.1Pra
targeted mutation 1.1, Pradip Raychaudhuri
MGI:5003269
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cul4atm1.1Pra/Cul4atm1.1Pra Not Specified MGI:5003281
cn2
 		Cul4atm1.1Pra/Cul4atm1.1Pra involves: C57BL/6NTac MGI:5003272
cn3
 		Cul4atm1.1Pra/Cul4atm1.1Pra
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: C57BL/6 * C57BL/6NTac * DBA MGI:5003273


Genotype
MGI:5003281
hm1
Allelic
Composition		 Cul4atm1.1Pra/Cul4atm1.1Pra
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul4atm1.1Pra mutation (0 available); any Cul4a mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:171470 )
N
• mice exhibit normal reproductive system morphology and function




Genotype
MGI:5003272
cn2
Allelic
Composition		 Cul4atm1.1Pra/Cul4atm1.1Pra
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul4atm1.1Pra mutation (0 available); any Cul4a mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal centrosome morphology ( J:172043 )
• mouse embryonic fibroblasts transfected with a cre-expressing adenovirus exhibit centrosomal aberrations
abnormal cell cycle checkpoint function ( J:172043 )
• mouse embryonic fibroblasts transfected with a cre-expressing adenovirus exhibit delayed entry into S phase and M phase and progression through early mitosis compared with control cells
increased cellular sensitivity to ultraviolet irradiation ( J:172043 )
• in mouse embryonic fibroblasts transfected with a cre-expressing adenovirus
decreased fibroblast proliferation ( J:172043 )
• decreased cell proliferation in mouse embryonic fibroblasts transfected with a cre-expressing adenovirus
• however, inhibition of Trp53 reverses proliferation defects
abnormal DNA replication ( J:172043 )
• UV-irradiated mouse embryonic fibroblasts transfected with a cre-expressing adenovirus are deficient in unscheduled DNA synthesis unlike control cells
chromosomal instability ( J:172043 )
• mouse embryonic fibroblasts transfected with a cre-expressing adenovirus exhibit centrosomal aberrations, multipolar spindle, and a 2.5-fold increased in micronuclei compared with control cells

homeostasis/metabolism
abnormal DNA replication ( J:172043 )
• UV-irradiated mouse embryonic fibroblasts transfected with a cre-expressing adenovirus are deficient in unscheduled DNA synthesis unlike control cells




Genotype
MGI:5003273
cn3
Allelic
Composition		 Cul4atm1.1Pra/Cul4atm1.1Pra
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: C57BL/6 * C57BL/6NTac * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul4atm1.1Pra mutation (0 available); any Cul4a mutation (30 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
decreased hepatocyte proliferation ( J:172043 )
• following CCl4 injury

growth/size/body
decreased body weight ( J:172043 )

homeostasis/metabolism
increased susceptibility to injury ( J:172043 )
• following CCl4 injury, mice exhibit decreased hepatocyte proliferation compared with control mice

cellular
decreased hepatocyte proliferation ( J:172043 )
• following CCl4 injury




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory