Phenotypes associated with this allele

• Allele Symbol: Cul4a^tm1.1Pra
• Allele Name: targeted mutation 1.1, Pradip Raychaudhuri
• Allele ID: MGI:5003269
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cul4a^tm1.1Pra/Cul4a^tm1.1Pra	Not Specified	MGI:5003281
cn2	Cul4a^tm1.1Pra/Cul4a^tm1.1Pra	involves: C57BL/6NTac	MGI:5003272
cn3	Cul4a^tm1.1Pra/Cul4a^tm1.1Pra Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: C57BL/6 * C57BL/6NTac * DBA	MGI:5003273

Genotype
MGI:5003281

hm1

• Allelic Composition: Cul4a^tm1.1Pra/Cul4a^tm1.1Pra
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:171470 )

N • mice exhibit normal reproductive system morphology and function

Genotype
MGI:5003272

cn2

• Allelic Composition: Cul4a^tm1.1Pra/Cul4a^tm1.1Pra
• Genetic Background: involves: C57BL/6NTac

cellular

abnormal centrosome morphology ( J:172043 )

• mouse embryonic fibroblasts transfected with a cre-expressing adenovirus exhibit centrosomal aberrations

abnormal cell cycle checkpoint function ( J:172043 )

• mouse embryonic fibroblasts transfected with a cre-expressing adenovirus exhibit delayed entry into S phase and M phase and progression through early mitosis compared with control cells

increased cellular sensitivity to ultraviolet irradiation ( J:172043 )

• in mouse embryonic fibroblasts transfected with a cre-expressing adenovirus

decreased fibroblast proliferation ( J:172043 )

• decreased cell proliferation in mouse embryonic fibroblasts transfected with a cre-expressing adenovirus

• however, inhibition of Trp53 reverses proliferation defects

abnormal DNA replication ( J:172043 )

• UV-irradiated mouse embryonic fibroblasts transfected with a cre-expressing adenovirus are deficient in unscheduled DNA synthesis unlike control cells

chromosomal instability ( J:172043 )

• mouse embryonic fibroblasts transfected with a cre-expressing adenovirus exhibit centrosomal aberrations, multipolar spindle, and a 2.5-fold increased in micronuclei compared with control cells

homeostasis/metabolism

abnormal DNA replication ( J:172043 )

• UV-irradiated mouse embryonic fibroblasts transfected with a cre-expressing adenovirus are deficient in unscheduled DNA synthesis unlike control cells

Genotype
MGI:5003273

cn3

• Allelic Composition: Cul4a^tm1.1Pra/Cul4a^tm1.1Pra; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: C57BL/6 * C57BL/6NTac * DBA

liver/biliary system

decreased hepatocyte proliferation ( J:172043 )

• following CCl4 injury

growth/size/body

decreased body weight ( J:172043 )

homeostasis/metabolism

increased susceptibility to injury ( J:172043 )

• following CCl4 injury, mice exhibit decreased hepatocyte proliferation compared with control mice

cellular

decreased hepatocyte proliferation ( J:172043 )

• following CCl4 injury