Phenotypes associated with this allele

• Allele Symbol: Osr1^tm2.1Jian
• Allele Name: targeted mutation 2.2, Rulang Jiang
• Allele ID: MGI:5003112
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Osr1^tm2.1Jian/Osr1^tm2.1Jian	involves: 129S1/Sv	MGI:5003145
hm2	Osr1^tm2.1Jian/Osr1^tm2.1Jian	involves: 129S1/Sv * FVB/N	MGI:5004969

Genotype
MGI:5003145

hm1

• Allelic Composition: Osr1^tm2.1Jian/Osr1^tm2.1Jian
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

abnormal survival ( J:171478 )

• authors state that mice recapitulate the phenotype of Osr1^tm1Jian homozygotes

reproductive system

abnormal reproductive system morphology ( J:171478 )

• authors state that mice recapitulate the phenotype of Osr1^tm1Jian homozygotes

cardiovascular system

abnormal cardiovascular system morphology ( J:171478 )

• authors state that mice recapitulate the phenotype of Osr1^tm1Jian homozygotes

Genotype
MGI:5004969

hm2

• Allelic Composition: Osr1^tm2.1Jian/Osr1^tm2.1Jian
• Genetic Background: involves: 129S1/Sv * FVB/N

Dilated epicardium, hemorrhaging, and edema in Osr1^tm2.1Jian/Osr1^tm2.1Jian embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:172133 )

• mice die around E12.0

embryo

embryonic growth arrest ( J:172133 )

abnormal forelimb bud morphology ( J:172133 )

• at E12.0, forelimb buds are abnormal compared with wild-type mice

cardiovascular system

abnormal epicardium morphology ( J:172133 )

• dilated epicardium

hemorrhage ( J:172133 )

• in the trunk

limbs/digits/tail

abnormal forelimb bud morphology ( J:172133 )

• at E12.0, forelimb buds are abnormal compared with wild-type mice

homeostasis/metabolism

edema ( J:172133 )

• generalized in mice that survive to mid-gestation